Anaphase lag as the most likely mechanism for monosomy X in direct cytotrophoblasts but not in mesenchymal core cells from the same villi

Mazin B. Qumsiyeh, Avirachan T. Tharapel, Lee P. Shulman, Joe Leigh Simpson, Sherman Elias

Research output: Contribution to journalArticlepeer-review

5 Scopus citations

Abstract

A 36 year old white female was reffered for chorionic villus sampling for advanced maternal age. Direct (cytotrophoblast) preparations of chorionic villi were 45,X, but cultured mesenchymal core cells from the same villi were 46,XX. Study of embryonic and extraembryonic tissues showed the aneuploidy to be limited to cytotrophoblasts from specific placental sites. In aggregate, the cytogenetic findings can best be explained by anaphase lag during development of the cytotrophoblast, suggesting that this cytological mechanism and not non-disjunction is responsible for the common occurrence of monosomy X in villi.

Original languageEnglish (US)
Pages (from-to)780-781
Number of pages2
JournalJournal of medical genetics
Volume27
Issue number12
DOIs
StatePublished - 1990

ASJC Scopus subject areas

  • Genetics
  • Genetics(clinical)

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