TY - JOUR
T1 - Anaphase lag as the most likely mechanism for monosomy X in direct cytotrophoblasts but not in mesenchymal core cells from the same villi
AU - Qumsiyeh, Mazin B.
AU - Tharapel, Avirachan T.
AU - Shulman, Lee P.
AU - Simpson, Joe Leigh
AU - Elias, Sherman
PY - 1990
Y1 - 1990
N2 - A 36 year old white female was reffered for chorionic villus sampling for advanced maternal age. Direct (cytotrophoblast) preparations of chorionic villi were 45,X, but cultured mesenchymal core cells from the same villi were 46,XX. Study of embryonic and extraembryonic tissues showed the aneuploidy to be limited to cytotrophoblasts from specific placental sites. In aggregate, the cytogenetic findings can best be explained by anaphase lag during development of the cytotrophoblast, suggesting that this cytological mechanism and not non-disjunction is responsible for the common occurrence of monosomy X in villi.
AB - A 36 year old white female was reffered for chorionic villus sampling for advanced maternal age. Direct (cytotrophoblast) preparations of chorionic villi were 45,X, but cultured mesenchymal core cells from the same villi were 46,XX. Study of embryonic and extraembryonic tissues showed the aneuploidy to be limited to cytotrophoblasts from specific placental sites. In aggregate, the cytogenetic findings can best be explained by anaphase lag during development of the cytotrophoblast, suggesting that this cytological mechanism and not non-disjunction is responsible for the common occurrence of monosomy X in villi.
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U2 - 10.1136/jmg.27.12.780
DO - 10.1136/jmg.27.12.780
M3 - Article
C2 - 2074563
AN - SCOPUS:0025242621
SN - 0022-2593
VL - 27
SP - 780
EP - 781
JO - Journal of medical genetics
JF - Journal of medical genetics
IS - 12
ER -