Anaplastic Lymphoma Kinase Mutation-Positive Non-Small Cell Lung Cancer

Anthony V. Serritella, Christine M. Bestvina

Research output: Contribution to journalReview article

Abstract

The treatment of patients with advanced non-small cell lung cancer with anaplastic lymphoma kinase chromosomal rearrangements has been revolutionized by the development of tyrosine kinase inhibitors (TKIs). Excellent progress has been made over the past decade, with 4 TKIs now approved in the front-line setting. Alectinib is the preferred first-line option based on its efficacy and side-effect profile. The central nervous system (CNS) activity of alectinib and brigatinib has allowed for treatment of CNS metastases with TKI therapy. Once resistance inevitably develops, newer therapies such as lorlatinib can be considered.

Original languageEnglish (US)
Pages (from-to)137-146
Number of pages10
JournalThoracic surgery clinics
Volume30
Issue number2
DOIs
StatePublished - May 1 2020
Externally publishedYes

Keywords

  • Alectinib
  • Anaplastic lymphoma kinase (ALK)
  • Brigatinib
  • Ceritinib
  • Crizotinib
  • Lorlatinib
  • Non–small cell lung cancer

ASJC Scopus subject areas

  • Surgery
  • Pulmonary and Respiratory Medicine

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