Anaplastic thyroid carcinoma with rhabdoid features

Gong Feng, William B. Laskin, Pauline M Chou, Xiaoqi Lin*

*Corresponding author for this work

Research output: Contribution to journalArticle

7 Citations (Scopus)

Abstract

Anaplastic thyroid carcinoma (ATC) is a rare, highly aggressive neoplasm, characterized by complete or partial composition by undifferentiated cells. We report a case of ATC with rhabdoid features in a 68-year-old male, who presented with a rapidly enlarging neck mass. Fine-needle aspiration (FNA) of the thyroid mass showed discohesive, pleomorphic round to polygonal rhabdoid cells with one to multiple eccentric, large, rounded nuclei with a prominent nucleolus, moderate to abundant, globoid cytoplasm which oftentimes harbor a pale para-nuclear inclusion. The cytoplasm of some cells contained variously sized, eosinophilic granules. Rare cells contained neutrophils in their cytoplasm. Mitoses including atypical mitotic figures and necrosis were readily seen. Histologic examination of needle core biopsy (NCB) revealed individual dispersed and sheets of pleomorphic neoplastic cells with similar cytomorphologic features as described above. The tumor extensively infiltrated a myxocollagenous stroma containing lymphocytes and neutrophils, and demonstrated foci of necrosis. Tumor cells were immunoreactive for keratins AE1/AE3, CAM5.2, and CK19; PAX-8, and p63, but negative for S-100, HMB-45, calcitonin, TTF-1, thyroglobulin, CD56, HBME-1, glypican-3, PAX-5, myogenin, CD31, and INI-1. The differential diagnosis of this malignant rhabdoid tumor is discussed. Diagn. Cytopathol. 2015;43:416-420.

Original languageEnglish (US)
Pages (from-to)416-420
Number of pages5
JournalDiagnostic Cytopathology
Volume43
Issue number5
DOIs
StatePublished - May 1 2015

Fingerprint

Cytoplasm
Neutrophils
Necrosis
Glypicans
Rhabdoid Tumor
Myogenin
Large-Core Needle Biopsy
Intranuclear Inclusion Bodies
Neoplasms
Thyroglobulin
Calcitonin
Keratins
Fine Needle Biopsy
Mitosis
Anaplastic Thyroid Carcinoma
Thyroid Gland
Differential Diagnosis
Neck
Lymphocytes
CAM 5.2 antigen

Keywords

  • anaplastic thyroid carcinoma
  • cytology
  • fine-needle aspiration
  • immunohistochemicstry
  • rhabdoid cells

ASJC Scopus subject areas

  • Pathology and Forensic Medicine
  • Histology

Cite this

Feng, Gong ; Laskin, William B. ; Chou, Pauline M ; Lin, Xiaoqi. / Anaplastic thyroid carcinoma with rhabdoid features. In: Diagnostic Cytopathology. 2015 ; Vol. 43, No. 5. pp. 416-420.
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Anaplastic thyroid carcinoma with rhabdoid features. / Feng, Gong; Laskin, William B.; Chou, Pauline M; Lin, Xiaoqi.

In: Diagnostic Cytopathology, Vol. 43, No. 5, 01.05.2015, p. 416-420.

Research output: Contribution to journalArticle

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AB - Anaplastic thyroid carcinoma (ATC) is a rare, highly aggressive neoplasm, characterized by complete or partial composition by undifferentiated cells. We report a case of ATC with rhabdoid features in a 68-year-old male, who presented with a rapidly enlarging neck mass. Fine-needle aspiration (FNA) of the thyroid mass showed discohesive, pleomorphic round to polygonal rhabdoid cells with one to multiple eccentric, large, rounded nuclei with a prominent nucleolus, moderate to abundant, globoid cytoplasm which oftentimes harbor a pale para-nuclear inclusion. The cytoplasm of some cells contained variously sized, eosinophilic granules. Rare cells contained neutrophils in their cytoplasm. Mitoses including atypical mitotic figures and necrosis were readily seen. Histologic examination of needle core biopsy (NCB) revealed individual dispersed and sheets of pleomorphic neoplastic cells with similar cytomorphologic features as described above. The tumor extensively infiltrated a myxocollagenous stroma containing lymphocytes and neutrophils, and demonstrated foci of necrosis. Tumor cells were immunoreactive for keratins AE1/AE3, CAM5.2, and CK19; PAX-8, and p63, but negative for S-100, HMB-45, calcitonin, TTF-1, thyroglobulin, CD56, HBME-1, glypican-3, PAX-5, myogenin, CD31, and INI-1. The differential diagnosis of this malignant rhabdoid tumor is discussed. Diagn. Cytopathol. 2015;43:416-420.

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