Anatomic and Physiologic Changes of the Aging Kidney

Zeina Karam, Jennifer A Tuazon*

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review

42 Scopus citations


Aging is associated with structural and functional changes in the kidney. Structural changes include glomerulosclerosis, thickening of the basement membrane, increase in mesangial matrix, tubulointerstitial fibrosis and arteriosclerosis. Glomerular filtration rate is maintained until the fourth decade of life, after which it declines. Parallel reductions in renal blood flow occur with redistribution of blood flow from the cortex to the medulla. Other functional changes include an increase in glomerular basement permeability and decreased ability to dilute or concentrate urine.

Original languageEnglish (US)
Pages (from-to)555-564
Number of pages10
JournalClinics in Geriatric Medicine
Issue number3
StatePublished - Aug 1 2013


  • Functional reserve
  • Glomerular filtration rate
  • Glomerulosclerosis
  • Osmoregulation
  • Renal blood flow
  • Renal mass
  • Renin-angiotensin system
  • Senescence

ASJC Scopus subject areas

  • Geriatrics and Gerontology


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