Abstract
Aging is associated with structural and functional changes in the kidney. Structural changes include glomerulosclerosis, thickening of the basement membrane, increase in mesangial matrix, tubulointerstitial fibrosis and arteriosclerosis. Glomerular filtration rate is maintained until the fourth decade of life, after which it declines. Parallel reductions in renal blood flow occur with redistribution of blood flow from the cortex to the medulla. Other functional changes include an increase in glomerular basement permeability and decreased ability to dilute or concentrate urine.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 555-564 |
| Number of pages | 10 |
| Journal | Clinics in Geriatric Medicine |
| Volume | 29 |
| Issue number | 3 |
| DOIs | |
| State | Published - Aug 2013 |
Keywords
- Functional reserve
- Glomerular filtration rate
- Glomerulosclerosis
- Osmoregulation
- Renal blood flow
- Renal mass
- Renin-angiotensin system
- Senescence
ASJC Scopus subject areas
- Geriatrics and Gerontology