TY - JOUR
T1 - Ancestry-environment interactions and asthma risk among Puerto Ricans
AU - Choudhry, Shweta
AU - Burchard, Esteban González
AU - Borrell, Luisa N.
AU - Tang, Hua
AU - Gomez, Ivan
AU - Naqvi, Mariam
AU - Nazario, Sylvette
AU - Torres, Alphonso
AU - Casal, Jesus
AU - Martinez-Cruzado, Juan Carlos
AU - Ziv, Elad
AU - Avila, Pedro C.
AU - Rodriguez-Cintron, William
AU - Risch, Neil J.
PY - 2006/11/15
Y1 - 2006/11/15
N2 - Background: Puerto Ricans, an admixed population of African, European, and Native American ancestries, have the highest asthma prevalence, morbidity, and mortality rates of any United States' population. Although socioeconomic status (SES) is negatively correlated with asthma incidence in most populations, nosuch relationship has been identified among Puerto Ricans. We hypothesized that, in this admixed population, the association between SES and asthma may interact with genetic ancestry. Methods: We analyzed 135 Puerto Rican subjects with asthma and 156 control subjects recruited from six different recruitment centers in Puerto Rico. Individual ancestry for each subject was estimated using 44 ancestry informative markers. SES was assigned using the census tracts' median family income. Analyses of SES were based on the SES of the clinic site from which the subjects were recruited and on a subset of individuals on whom home address-based SES was available. Results: In the two (independent) analyses, we found a significant interaction between SES, ancestry, and asthma disease status. At lower SES, European ancestry was associated with increased risk of asthma, whereas African ancestry was associated with decreased risk. The opposite was true for their higher SES counterparts. Conclusions: The observed interaction may help to explain the unique pattern of risk for asthma in Puerto Ricans and the lack of association with SES observed in previous studies when not accounting for varying proportions of ancestry.
AB - Background: Puerto Ricans, an admixed population of African, European, and Native American ancestries, have the highest asthma prevalence, morbidity, and mortality rates of any United States' population. Although socioeconomic status (SES) is negatively correlated with asthma incidence in most populations, nosuch relationship has been identified among Puerto Ricans. We hypothesized that, in this admixed population, the association between SES and asthma may interact with genetic ancestry. Methods: We analyzed 135 Puerto Rican subjects with asthma and 156 control subjects recruited from six different recruitment centers in Puerto Rico. Individual ancestry for each subject was estimated using 44 ancestry informative markers. SES was assigned using the census tracts' median family income. Analyses of SES were based on the SES of the clinic site from which the subjects were recruited and on a subset of individuals on whom home address-based SES was available. Results: In the two (independent) analyses, we found a significant interaction between SES, ancestry, and asthma disease status. At lower SES, European ancestry was associated with increased risk of asthma, whereas African ancestry was associated with decreased risk. The opposite was true for their higher SES counterparts. Conclusions: The observed interaction may help to explain the unique pattern of risk for asthma in Puerto Ricans and the lack of association with SES observed in previous studies when not accounting for varying proportions of ancestry.
KW - Admixture
KW - Asthma
KW - Gene-environment
KW - Latino
KW - Socioeconomic status
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U2 - 10.1164/rccm.200605-596OC
DO - 10.1164/rccm.200605-596OC
M3 - Article
C2 - 16973984
AN - SCOPUS:33750435382
SN - 1073-449X
VL - 174
SP - 1088
EP - 1093
JO - American journal of respiratory and critical care medicine
JF - American journal of respiratory and critical care medicine
IS - 10
ER -
