Androgens and prostate cancer: Are the descriptors valid?

Pradip Roy-Burman*, Donald J. Tindall, Diane M. Robins, Norman M. Greenberg, Mary J.C. Hendrix, Suresh Mohla, Robert H. Getzenberg, John T. Isaacs, Kenneth J. Pienta

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

41 Scopus citations


The term androgen-independent cancer has now become a misnomer. Given that the androgen receptor can be activated by even low androgen concentrations or via protein modifications or other protein-protein interactions, a growing prostate cancer has the chance of assuming an androgen depletion-independent state, without necessarily bypassing the androgen signaling processes. It is thus suggested that "androgen-independent (Al)" cancer should be more accurately termed "androgen depletion-independent (ADI)" cancer.

Original languageEnglish (US)
Pages (from-to)4-5
Number of pages2
JournalCancer Biology and Therapy
Issue number1
StatePublished - Jan 2005

ASJC Scopus subject areas

  • Molecular Medicine
  • Oncology
  • Cancer Research
  • Pharmacology


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