Angiogenesehemmungin der neuroonkologie. Eine vielversprechende therapiestrategie gegen maligne Gliome

Translated title of the contribution: Angiogenesis inhibition in neurooncology. A very promising therapy strategy for malignant glioma

G. Tabatabai*, R. Stupp

*Corresponding author for this work

Research output: Contribution to journalArticle

Abstract

The application of angiogenesis inhibitors in neurooncology is increasing. Initially, these drugs seemed to be very promising because of the surprisingly high neuroradiological response rates that were observed in first clinical trials. Meanwhile, this enthusiasm is waning, as the high response rates did not translate into substantial improvements in progression-free and overall survival. Tumor progression during or after antiangiogenic therapy is often associated with rapid clinical neurological deterioration and sometimes even with diffuse infiltrative gliomatosis-like neuroradiological phenotypes. Thus, the characterization and understanding of escape mechanisms are needed. The identification of criteria for defining the personalized use of angiogenesis inhibitors remains a challenge.

Translated title of the contributionAngiogenesis inhibition in neurooncology. A very promising therapy strategy for malignant glioma
Original languageGerman
Pages (from-to)936-939
Number of pages4
JournalNervenarzt
Volume81
Issue number8
DOIs
StatePublished - Aug 2010

Keywords

  • Angiogenesis inhibition
  • Ascular endothelial growth factor
  • Neurooncology
  • Phenotype
  • Resistance mechanisms

ASJC Scopus subject areas

  • Neurology
  • Clinical Neurology
  • Psychiatry and Mental health

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