Angiographic estimates of myocardium at risk during acute myocardial infarction: Validation study using cardiac magnetic resonance imaging

José T. Ortiz-Pérez*, Sheridan N. Meyers, Daniel C. Lee, Preeti Kansal, Francis J. Klocke, Thomas A. Holly, Charles J. Davidson, Robert O. Bonow, Edwin Wu

*Corresponding author for this work

Research output: Contribution to journalArticle

121 Scopus citations

Abstract

Aims: Global angiographic scores have been developed to determine the extent of myocardium jeopardized by significant coronary stenosis. We adapted these scores to quantify the anatomic area at risk during acute myocardial infarction. We used contrast-enhanced magnetic resonance (CMR) infarct imaging to measure the portion of myocardium that developed necrosis within the so defined angiographic area at risk. Methods and results: In 83 subjects presenting for primary percutaneous intervention, the myocardium at risk was estimated angiographically using the Myocardial Jeopardy Index (BARI) and a modified version of the Alberta Provincial Project for Outcome Assessment in Coronary Heart Disease (APPROACH) scores. CMR was performed within a week to measure infarct size, infarct endocardial surface area (infarct-ESA), and infarct transmurality. As infarct transmurality increased, the infarct size closely approximated the myocardium at risk by angiography. In 35 subjects with transmural infarcts, the area at risk by BARI and APPROACH scores matched the infarct size (r = 0.90 and r = 0.92, P < 0.001). Additionally, BARI and APPROACH scores matched the infarct-ESA in all subjects independently of collateral flow and time to reperfusion (r = 0.90 and r = 0.87, P < 0.001). The presence of early reperfusion, collaterals, or both was associated with a progressive decrease in infarct transmurality (P < 0.001 for trend) with no difference in the infarct-ESA. Conclusion: The myocardium at risk of infarction can be determined angiographically as validated in subjects with transmural myocardial infarcts. Salvage provided by early reperfusion or collaterals occurs by limiting infarct transmurality, thereby the extent of endocardial infarct involved also allows estimation of the myocardium at risk in patients presenting with STEMI.

Original languageEnglish (US)
Pages (from-to)1750-1758
Number of pages9
JournalEuropean Heart Journal
Volume28
Issue number14
DOIs
StatePublished - Jun 1 2007

Keywords

  • Area at risk
  • Cardiac magnetic resonance
  • Collaterals
  • Coronary angiography
  • Myocardial infarction
  • Time to reperfusion

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

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