Angiopoietin-2: Development of inhibitors for cancer therapy

Bo Hu, Shi Yuan Cheng*

*Corresponding author for this work

Research output: Contribution to journalReview article

77 Citations (Scopus)

Abstract

Angiopoietin-2 (Ang2) is a member of the Ang family, which plays an important role in angiogenesis during the development and growth of human cancers. Ang2's role in angiogenesis generally is considered as an antagonist for Ang1, inhibiting Ang1-promoted Tie2 signaling, which is critical for blood vessel maturation and stabilization. Ang2 modulates angiogenesis in a cooperative manner with another important angiogenic factor, vascular endothelial growth factor A. Genetic studies have revealed that Ang2 also is critical in lymphangiogenesis during development. However, new evidence suggests more complicated roles for Ang2 in angiogenesis in physiologic processes and invasive phenotypes of cancer cells during progression of human cancers. This article discusses recent studies of Ang2 in angiogenesis and the implication of Ang2 as a therapeutic target as well as a potential inhibitor for antiangiogenesis treatment for cancer patients.

Original languageEnglish (US)
Pages (from-to)111-116
Number of pages6
JournalCurrent oncology reports
Volume11
Issue number2
DOIs
StatePublished - Feb 23 2009

Fingerprint

Angiopoietin-2
Neoplasms
Therapeutics
Physiologic Neovascularization
Lymphangiogenesis
Angiogenesis Inducing Agents
Human Development
Growth and Development
Vascular Endothelial Growth Factor A
Blood Vessels
Phenotype

ASJC Scopus subject areas

  • Oncology

Cite this

@article{d7fecf5fd03e498088a42276bb000e5f,
title = "Angiopoietin-2: Development of inhibitors for cancer therapy",
abstract = "Angiopoietin-2 (Ang2) is a member of the Ang family, which plays an important role in angiogenesis during the development and growth of human cancers. Ang2's role in angiogenesis generally is considered as an antagonist for Ang1, inhibiting Ang1-promoted Tie2 signaling, which is critical for blood vessel maturation and stabilization. Ang2 modulates angiogenesis in a cooperative manner with another important angiogenic factor, vascular endothelial growth factor A. Genetic studies have revealed that Ang2 also is critical in lymphangiogenesis during development. However, new evidence suggests more complicated roles for Ang2 in angiogenesis in physiologic processes and invasive phenotypes of cancer cells during progression of human cancers. This article discusses recent studies of Ang2 in angiogenesis and the implication of Ang2 as a therapeutic target as well as a potential inhibitor for antiangiogenesis treatment for cancer patients.",
author = "Bo Hu and Cheng, {Shi Yuan}",
year = "2009",
month = "2",
day = "23",
doi = "10.1007/s11912-009-0017-3",
language = "English (US)",
volume = "11",
pages = "111--116",
journal = "Current Oncology Reports",
issn = "1523-3790",
publisher = "Current Science, Inc.",
number = "2",

}

Angiopoietin-2 : Development of inhibitors for cancer therapy. / Hu, Bo; Cheng, Shi Yuan.

In: Current oncology reports, Vol. 11, No. 2, 23.02.2009, p. 111-116.

Research output: Contribution to journalReview article

TY - JOUR

T1 - Angiopoietin-2

T2 - Development of inhibitors for cancer therapy

AU - Hu, Bo

AU - Cheng, Shi Yuan

PY - 2009/2/23

Y1 - 2009/2/23

N2 - Angiopoietin-2 (Ang2) is a member of the Ang family, which plays an important role in angiogenesis during the development and growth of human cancers. Ang2's role in angiogenesis generally is considered as an antagonist for Ang1, inhibiting Ang1-promoted Tie2 signaling, which is critical for blood vessel maturation and stabilization. Ang2 modulates angiogenesis in a cooperative manner with another important angiogenic factor, vascular endothelial growth factor A. Genetic studies have revealed that Ang2 also is critical in lymphangiogenesis during development. However, new evidence suggests more complicated roles for Ang2 in angiogenesis in physiologic processes and invasive phenotypes of cancer cells during progression of human cancers. This article discusses recent studies of Ang2 in angiogenesis and the implication of Ang2 as a therapeutic target as well as a potential inhibitor for antiangiogenesis treatment for cancer patients.

AB - Angiopoietin-2 (Ang2) is a member of the Ang family, which plays an important role in angiogenesis during the development and growth of human cancers. Ang2's role in angiogenesis generally is considered as an antagonist for Ang1, inhibiting Ang1-promoted Tie2 signaling, which is critical for blood vessel maturation and stabilization. Ang2 modulates angiogenesis in a cooperative manner with another important angiogenic factor, vascular endothelial growth factor A. Genetic studies have revealed that Ang2 also is critical in lymphangiogenesis during development. However, new evidence suggests more complicated roles for Ang2 in angiogenesis in physiologic processes and invasive phenotypes of cancer cells during progression of human cancers. This article discusses recent studies of Ang2 in angiogenesis and the implication of Ang2 as a therapeutic target as well as a potential inhibitor for antiangiogenesis treatment for cancer patients.

UR - http://www.scopus.com/inward/record.url?scp=60349121010&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=60349121010&partnerID=8YFLogxK

U2 - 10.1007/s11912-009-0017-3

DO - 10.1007/s11912-009-0017-3

M3 - Review article

C2 - 19216842

AN - SCOPUS:60349121010

VL - 11

SP - 111

EP - 116

JO - Current Oncology Reports

JF - Current Oncology Reports

SN - 1523-3790

IS - 2

ER -