Angiotensin II subtype 1 receptor blockade inhibits Clostridium difficile toxin A-induced intestinal secretion in a rabbit model

Cirle S. Alcantara, Xiao Hong Jin, Gerly Anne C Brito, Benedito A. Carneiro-Filho, Leah J. Barrett, Robert M. Carey, Richard L. Guerrant*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

10 Scopus citations

Abstract

Angiotensin II (ANG II) has been described in the regulation of intestinal secretion and absorption via angiotensin subtype 1 (AT1) and AT 2 receptors, respectively, in rats. We investigated the role that ANG II plays in the rabbit ileal-loop model of Clostridium difficile infection. Expression of AT1, the more abundant ANG II receptor, was demonstrated in ileal loops, and an AT, receptor blocker, losartan, inhibited hypersecretion induced by C. difficile toxin A (mean volume:length ratio, 0.27 ± 0.06 vs. 0.60 ± 0.06 mL/cm in controls). Losartan also decreased production of ANG II in the ileum (0.48 ± 0.06 vs. 0.87 ± 0.12 pg/mg in controls), raising the possibility that ANG II may participate in a positive feedback loop involving the hypersecretory response. Our findings suggest that ANG II plays a significant role in the pathogenesis of C. difficile toxin-induced diarrhea.

Original languageEnglish (US)
Pages (from-to)2090-2096
Number of pages7
JournalJournal of Infectious Diseases
Volume191
Issue number12
DOIs
StatePublished - Jun 15 2005

ASJC Scopus subject areas

  • Immunology and Allergy
  • Infectious Diseases

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