TY - JOUR
T1 - Angiotensin II subtype 1 receptor blockade inhibits Clostridium difficile toxin A-induced intestinal secretion in a rabbit model
AU - Alcantara, Cirle S.
AU - Jin, Xiao Hong
AU - Brito, Gerly Anne C
AU - Carneiro-Filho, Benedito A.
AU - Barrett, Leah J.
AU - Carey, Robert M.
AU - Guerrant, Richard L.
N1 - Funding Information:
Received 19 May 2004; accepted 12 January 2005; electronically published 3 May 2005. Presented in part: 50th Annual Meeting of the American Society of Tropical Medicine and Hygiene, Atlanta, GA, 11–15 November 2001. Financial support: Fogarty International Center Training and Research in Emerging Infectious Diseases Fellowship (grant 5 D43 TW00909 to C.S.A.). Reprints or correspondence: Dr. Richard L. Guerrant, Center for Global Health, Div. of Infectious Disease and International Health, University of Virginia Health Sciences Center, PO Box 801379, Charlottesville, VA 22903-1379 ([email protected].).
PY - 2005/6/15
Y1 - 2005/6/15
N2 - Angiotensin II (ANG II) has been described in the regulation of intestinal secretion and absorption via angiotensin subtype 1 (AT1) and AT 2 receptors, respectively, in rats. We investigated the role that ANG II plays in the rabbit ileal-loop model of Clostridium difficile infection. Expression of AT1, the more abundant ANG II receptor, was demonstrated in ileal loops, and an AT, receptor blocker, losartan, inhibited hypersecretion induced by C. difficile toxin A (mean volume:length ratio, 0.27 ± 0.06 vs. 0.60 ± 0.06 mL/cm in controls). Losartan also decreased production of ANG II in the ileum (0.48 ± 0.06 vs. 0.87 ± 0.12 pg/mg in controls), raising the possibility that ANG II may participate in a positive feedback loop involving the hypersecretory response. Our findings suggest that ANG II plays a significant role in the pathogenesis of C. difficile toxin-induced diarrhea.
AB - Angiotensin II (ANG II) has been described in the regulation of intestinal secretion and absorption via angiotensin subtype 1 (AT1) and AT 2 receptors, respectively, in rats. We investigated the role that ANG II plays in the rabbit ileal-loop model of Clostridium difficile infection. Expression of AT1, the more abundant ANG II receptor, was demonstrated in ileal loops, and an AT, receptor blocker, losartan, inhibited hypersecretion induced by C. difficile toxin A (mean volume:length ratio, 0.27 ± 0.06 vs. 0.60 ± 0.06 mL/cm in controls). Losartan also decreased production of ANG II in the ileum (0.48 ± 0.06 vs. 0.87 ± 0.12 pg/mg in controls), raising the possibility that ANG II may participate in a positive feedback loop involving the hypersecretory response. Our findings suggest that ANG II plays a significant role in the pathogenesis of C. difficile toxin-induced diarrhea.
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U2 - 10.1086/430316
DO - 10.1086/430316
M3 - Article
C2 - 15897995
AN - SCOPUS:20444407608
SN - 0022-1899
VL - 191
SP - 2090
EP - 2096
JO - Journal of Infectious Diseases
JF - Journal of Infectious Diseases
IS - 12
ER -
