Anhedonia in combat veterans with penetrating head injury

Jeffrey D. Lewis, Frank Krueger, Vanessa Raymont, Jeffrey Solomon, Kristine M. Knutson, Aron K. Barbey, Joshua C. Poore, Eric M. Wassermann*, Jordan Grafman

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

4 Scopus citations


Anhedonia is a common symptom following traumatic brain injury. The neural basis of anhedonia is poorly understood, but believed to involve disturbed reward processing, rather than the loss of sense of pleasure. This analysis was undertaken to determine if injury to specific regions of prefrontal cortex (PFC) result in anhedonia. A CT-based lesion analysis was undertaken in 192 participants of the Vietnam Head Injury Study, most with penetrating head injury. Participants were divided into left and right ventrolateral prefrontal, bilateral ventromedial prefrontal, and other injury locations. Anhedonia was measured by self-report in each group using the four-item anhedonia subscale score of the Beck Depression Inventory-II. Individuals with right ventrolateral injury reported greater severity of anhedonia compared to those with injury in the left ventrolateral region. These findings support an association between injury in the right ventrolateral PFC and anhedonia.

Original languageEnglish (US)
Pages (from-to)456-460
Number of pages5
JournalBrain Imaging and Behavior
Issue number3
StatePublished - Sep 26 2015


  • Anhedonia
  • Depression
  • Motivational anhedonia
  • Reward
  • Traumatic brain injury
  • Ventrolateral prefrontal cortex

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging
  • Neurology
  • Clinical Neurology
  • Cognitive Neuroscience
  • Cellular and Molecular Neuroscience
  • Psychiatry and Mental health
  • Behavioral Neuroscience


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