Anhedonia in combat veterans with penetrating head injury

Jeffrey D. Lewis; Frank Krueger; Vanessa Raymont; Jeffrey Solomon; Kristine M. Knutson; Aron K. Barbey; Joshua C. Poore; Eric M. Wassermann; Jordan Grafman

doi:10.1007/s11682-015-9414-4

Anhedonia in combat veterans with penetrating head injury

Jeffrey D. Lewis, Frank Krueger, Vanessa Raymont, Jeffrey Solomon, Kristine M. Knutson, Aron K. Barbey, Joshua C. Poore, Eric M. Wassermann^*, Jordan Grafman

^*Corresponding author for this work

Physical Medicine and Rehabilitation

Research output: Contribution to journal › Article › peer-review

6 Scopus citations

Abstract

Anhedonia is a common symptom following traumatic brain injury. The neural basis of anhedonia is poorly understood, but believed to involve disturbed reward processing, rather than the loss of sense of pleasure. This analysis was undertaken to determine if injury to specific regions of prefrontal cortex (PFC) result in anhedonia. A CT-based lesion analysis was undertaken in 192 participants of the Vietnam Head Injury Study, most with penetrating head injury. Participants were divided into left and right ventrolateral prefrontal, bilateral ventromedial prefrontal, and other injury locations. Anhedonia was measured by self-report in each group using the four-item anhedonia subscale score of the Beck Depression Inventory-II. Individuals with right ventrolateral injury reported greater severity of anhedonia compared to those with injury in the left ventrolateral region. These findings support an association between injury in the right ventrolateral PFC and anhedonia.

Original language	English (US)
Pages (from-to)	456-460
Number of pages	5
Journal	Brain Imaging and Behavior
Volume	9
Issue number	3
DOIs	https://doi.org/10.1007/s11682-015-9414-4
State	Published - Sep 26 2015

Funding

Keywords

Anhedonia
Depression
Motivational anhedonia
Reward
Traumatic brain injury
Ventrolateral prefrontal cortex

ASJC Scopus subject areas

Clinical Neurology
Neurology
Psychiatry and Mental health
Cellular and Molecular Neuroscience
Cognitive Neuroscience
Radiology Nuclear Medicine and imaging
Behavioral Neuroscience

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

Access to Document

10.1007/s11682-015-9414-4

Cite this

@article{c0b9a1eea44a418da649f1d828b85f8c,

title = "Anhedonia in combat veterans with penetrating head injury",

abstract = "Anhedonia is a common symptom following traumatic brain injury. The neural basis of anhedonia is poorly understood, but believed to involve disturbed reward processing, rather than the loss of sense of pleasure. This analysis was undertaken to determine if injury to specific regions of prefrontal cortex (PFC) result in anhedonia. A CT-based lesion analysis was undertaken in 192 participants of the Vietnam Head Injury Study, most with penetrating head injury. Participants were divided into left and right ventrolateral prefrontal, bilateral ventromedial prefrontal, and other injury locations. Anhedonia was measured by self-report in each group using the four-item anhedonia subscale score of the Beck Depression Inventory-II. Individuals with right ventrolateral injury reported greater severity of anhedonia compared to those with injury in the left ventrolateral region. These findings support an association between injury in the right ventrolateral PFC and anhedonia.",

keywords = "Anhedonia, Depression, Motivational anhedonia, Reward, Traumatic brain injury, Ventrolateral prefrontal cortex",

author = "Lewis, {Jeffrey D.} and Frank Krueger and Vanessa Raymont and Jeffrey Solomon and Knutson, {Kristine M.} and Barbey, {Aron K.} and Poore, {Joshua C.} and Wassermann, {Eric M.} and Jordan Grafman",

note = "Publisher Copyright: {\textcopyright} 2015, Springer Science+Business Media New York (outside the USA).",

year = "2015",

month = sep,

day = "26",

doi = "10.1007/s11682-015-9414-4",

language = "English (US)",

volume = "9",

pages = "456--460",

journal = "Brain Imaging and Behavior",

issn = "1931-7557",

publisher = "Springer New York",

number = "3",

}

TY - JOUR

T1 - Anhedonia in combat veterans with penetrating head injury

AU - Lewis, Jeffrey D.

AU - Krueger, Frank

AU - Raymont, Vanessa

AU - Solomon, Jeffrey

AU - Knutson, Kristine M.

AU - Barbey, Aron K.

AU - Poore, Joshua C.

AU - Wassermann, Eric M.

AU - Grafman, Jordan

PY - 2015/9/26

Y1 - 2015/9/26

N2 - Anhedonia is a common symptom following traumatic brain injury. The neural basis of anhedonia is poorly understood, but believed to involve disturbed reward processing, rather than the loss of sense of pleasure. This analysis was undertaken to determine if injury to specific regions of prefrontal cortex (PFC) result in anhedonia. A CT-based lesion analysis was undertaken in 192 participants of the Vietnam Head Injury Study, most with penetrating head injury. Participants were divided into left and right ventrolateral prefrontal, bilateral ventromedial prefrontal, and other injury locations. Anhedonia was measured by self-report in each group using the four-item anhedonia subscale score of the Beck Depression Inventory-II. Individuals with right ventrolateral injury reported greater severity of anhedonia compared to those with injury in the left ventrolateral region. These findings support an association between injury in the right ventrolateral PFC and anhedonia.

AB - Anhedonia is a common symptom following traumatic brain injury. The neural basis of anhedonia is poorly understood, but believed to involve disturbed reward processing, rather than the loss of sense of pleasure. This analysis was undertaken to determine if injury to specific regions of prefrontal cortex (PFC) result in anhedonia. A CT-based lesion analysis was undertaken in 192 participants of the Vietnam Head Injury Study, most with penetrating head injury. Participants were divided into left and right ventrolateral prefrontal, bilateral ventromedial prefrontal, and other injury locations. Anhedonia was measured by self-report in each group using the four-item anhedonia subscale score of the Beck Depression Inventory-II. Individuals with right ventrolateral injury reported greater severity of anhedonia compared to those with injury in the left ventrolateral region. These findings support an association between injury in the right ventrolateral PFC and anhedonia.

KW - Anhedonia

KW - Depression

KW - Motivational anhedonia

KW - Reward

KW - Traumatic brain injury

KW - Ventrolateral prefrontal cortex

UR - http://www.scopus.com/inward/record.url?scp=84942372043&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84942372043&partnerID=8YFLogxK

U2 - 10.1007/s11682-015-9414-4

DO - 10.1007/s11682-015-9414-4

M3 - Article

C2 - 26049926

AN - SCOPUS:84942372043

SN - 1931-7557

VL - 9

SP - 456

EP - 460

JO - Brain Imaging and Behavior

JF - Brain Imaging and Behavior

IS - 3

ER -

Anhedonia in combat veterans with penetrating head injury

Abstract

Funding

Keywords

ASJC Scopus subject areas

UN SDGs

Access to Document

Other files and links

Fingerprint

Cite this