Anhedonia in combat veterans with penetrating head injury

Jeffrey D. Lewis, Frank Krueger, Vanessa Raymont, Jeffrey Solomon, Kristine M. Knutson, Aron K. Barbey, Joshua C. Poore, Eric M. Wassermann*, Jordan Henry Grafman

*Corresponding author for this work

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

Anhedonia is a common symptom following traumatic brain injury. The neural basis of anhedonia is poorly understood, but believed to involve disturbed reward processing, rather than the loss of sense of pleasure. This analysis was undertaken to determine if injury to specific regions of prefrontal cortex (PFC) result in anhedonia. A CT-based lesion analysis was undertaken in 192 participants of the Vietnam Head Injury Study, most with penetrating head injury. Participants were divided into left and right ventrolateral prefrontal, bilateral ventromedial prefrontal, and other injury locations. Anhedonia was measured by self-report in each group using the four-item anhedonia subscale score of the Beck Depression Inventory-II. Individuals with right ventrolateral injury reported greater severity of anhedonia compared to those with injury in the left ventrolateral region. These findings support an association between injury in the right ventrolateral PFC and anhedonia.

Original languageEnglish (US)
Pages (from-to)456-460
Number of pages5
JournalBrain Imaging and Behavior
Volume9
Issue number3
DOIs
StatePublished - Sep 26 2015

Fingerprint

Penetrating Head Injuries
Anhedonia
Veterans
Wounds and Injuries
Prefrontal Cortex
Pleasure
Vietnam
Reward
Craniocerebral Trauma
Self Report
Depression
Equipment and Supplies

Keywords

  • Anhedonia
  • Depression
  • Motivational anhedonia
  • Reward
  • Traumatic brain injury
  • Ventrolateral prefrontal cortex

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging
  • Neurology
  • Cognitive Neuroscience
  • Clinical Neurology
  • Cellular and Molecular Neuroscience
  • Psychiatry and Mental health
  • Behavioral Neuroscience

Cite this

Lewis, J. D., Krueger, F., Raymont, V., Solomon, J., Knutson, K. M., Barbey, A. K., ... Grafman, J. H. (2015). Anhedonia in combat veterans with penetrating head injury. Brain Imaging and Behavior, 9(3), 456-460. https://doi.org/10.1007/s11682-015-9414-4
Lewis, Jeffrey D. ; Krueger, Frank ; Raymont, Vanessa ; Solomon, Jeffrey ; Knutson, Kristine M. ; Barbey, Aron K. ; Poore, Joshua C. ; Wassermann, Eric M. ; Grafman, Jordan Henry. / Anhedonia in combat veterans with penetrating head injury. In: Brain Imaging and Behavior. 2015 ; Vol. 9, No. 3. pp. 456-460.
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Lewis, JD, Krueger, F, Raymont, V, Solomon, J, Knutson, KM, Barbey, AK, Poore, JC, Wassermann, EM & Grafman, JH 2015, 'Anhedonia in combat veterans with penetrating head injury', Brain Imaging and Behavior, vol. 9, no. 3, pp. 456-460. https://doi.org/10.1007/s11682-015-9414-4

Anhedonia in combat veterans with penetrating head injury. / Lewis, Jeffrey D.; Krueger, Frank; Raymont, Vanessa; Solomon, Jeffrey; Knutson, Kristine M.; Barbey, Aron K.; Poore, Joshua C.; Wassermann, Eric M.; Grafman, Jordan Henry.

In: Brain Imaging and Behavior, Vol. 9, No. 3, 26.09.2015, p. 456-460.

Research output: Contribution to journalArticle

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Lewis JD, Krueger F, Raymont V, Solomon J, Knutson KM, Barbey AK et al. Anhedonia in combat veterans with penetrating head injury. Brain Imaging and Behavior. 2015 Sep 26;9(3):456-460. https://doi.org/10.1007/s11682-015-9414-4