Animal models in the study of the unfolded protein response

Hemamalini Bommiasamy*, Brian Popko

*Corresponding author for this work

Research output: Chapter in Book/Report/Conference proceedingChapter

8 Scopus citations

Abstract

The endoplasmic reticulum, a highly dynamic and complex organelle, is the site for synthesis, folding, and modification of transmembrane and secretory proteins. Any disruptions to the endoplasmic reticulum such as an accumulation of misfolded or unfolded proteins results in activation of the unfolded protein response (UPR). The UPR is comprised of three distinct signal transduction pathways that work to restore homeostasis to the endoplasmic reticulum. This review summarizes select mouse models available to study the UPR and the information learned from the analyses of these models.

Original languageEnglish (US)
Title of host publicationMethods in Enzymology
PublisherAcademic Press Inc
Pages91-109
Number of pages19
DOIs
StatePublished - 2011

Publication series

NameMethods in Enzymology
Volume491
ISSN (Print)0076-6879

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Biology

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    Bommiasamy, H., & Popko, B. (2011). Animal models in the study of the unfolded protein response. In Methods in Enzymology (pp. 91-109). (Methods in Enzymology; Vol. 491). Academic Press Inc. https://doi.org/10.1016/B978-0-12-385928-0.00006-7