Antagonism of opiate-like, lanthanum-induced analgesia by naloxone, 2 mg/kg, in rats

J. Peter Rosenfeld; Michael Hammer

doi:10.1016/0006-8993(83)90408-0

Antagonism of opiate-like, lanthanum-induced analgesia by naloxone, 2 mg/kg, in rats

J. Peter Rosenfeld^*, Michael Hammer

^*Corresponding author for this work

Psychology

Research output: Contribution to journal › Article › peer-review

2 Scopus citations

Abstract

Lanthanum chloride (La⁺³; 1 mol) was microcannulated into the ventral central gray of rats. The latency to tail-flick and to face-rub (both evoked by noxious heat) was elevated to about 250% of a sham control condition. Naloxone, 2 mg/kg, antagonized the analgesia, reducing the latencies to values not different, in most cases, from control values.

Original language	English (US)
Pages (from-to)	189-191
Number of pages	3
Journal	Brain research
Volume	268
Issue number	1
DOIs	https://doi.org/10.1016/0006-8993(83)90408-0
State	Published - May 23 1983

Funding

This work was supported by NIH Grant GM 23696. We would like to thank ENDO Labs for donating the naloxone and R, Silvia, C. Porcel-lato and W. Seville for technical assistance.

Keywords

analgesia
central gray
lanthanum
naloxone
opiate receptors
pain

ASJC Scopus subject areas

Clinical Neurology
Molecular Biology
General Neuroscience
Developmental Biology

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10.1016/0006-8993(83)90408-0

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title = "Antagonism of opiate-like, lanthanum-induced analgesia by naloxone, 2 mg/kg, in rats",

abstract = "Lanthanum chloride (La+3; 1 mol) was microcannulated into the ventral central gray of rats. The latency to tail-flick and to face-rub (both evoked by noxious heat) was elevated to about 250% of a sham control condition. Naloxone, 2 mg/kg, antagonized the analgesia, reducing the latencies to values not different, in most cases, from control values.",

keywords = "analgesia, central gray, lanthanum, naloxone, opiate receptors, pain",

author = "Rosenfeld, {J. Peter} and Michael Hammer",

note = "Funding Information: This work was supported by NIH Grant GM 23696. We would like to thank ENDO Labs for donating the naloxone and R, Silvia, C. Porcel-lato and W. Seville for technical assistance.",

year = "1983",

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T1 - Antagonism of opiate-like, lanthanum-induced analgesia by naloxone, 2 mg/kg, in rats

AU - Rosenfeld, J. Peter

AU - Hammer, Michael

N1 - Funding Information: This work was supported by NIH Grant GM 23696. We would like to thank ENDO Labs for donating the naloxone and R, Silvia, C. Porcel-lato and W. Seville for technical assistance.

PY - 1983/5/23

Y1 - 1983/5/23

N2 - Lanthanum chloride (La+3; 1 mol) was microcannulated into the ventral central gray of rats. The latency to tail-flick and to face-rub (both evoked by noxious heat) was elevated to about 250% of a sham control condition. Naloxone, 2 mg/kg, antagonized the analgesia, reducing the latencies to values not different, in most cases, from control values.

AB - Lanthanum chloride (La+3; 1 mol) was microcannulated into the ventral central gray of rats. The latency to tail-flick and to face-rub (both evoked by noxious heat) was elevated to about 250% of a sham control condition. Naloxone, 2 mg/kg, antagonized the analgesia, reducing the latencies to values not different, in most cases, from control values.

KW - analgesia

KW - central gray

KW - lanthanum

KW - naloxone

KW - opiate receptors

KW - pain

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Antagonism of opiate-like, lanthanum-induced analgesia by naloxone, 2 mg/kg, in rats

Abstract

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Keywords

ASJC Scopus subject areas

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