Antagonism of opiate-like, lanthanum-induced analgesia by naloxone, 2 mg/kg, in rats

J. Peter Rosenfeld*, Michael Hammer

*Corresponding author for this work

Research output: Contribution to journalArticle

2 Scopus citations

Abstract

Lanthanum chloride (La+3; 1 mol) was microcannulated into the ventral central gray of rats. The latency to tail-flick and to face-rub (both evoked by noxious heat) was elevated to about 250% of a sham control condition. Naloxone, 2 mg/kg, antagonized the analgesia, reducing the latencies to values not different, in most cases, from control values.

Original languageEnglish (US)
Pages (from-to)189-191
Number of pages3
JournalBrain research
Volume268
Issue number1
DOIs
StatePublished - May 23 1983

Keywords

  • analgesia
  • central gray
  • lanthanum
  • naloxone
  • opiate receptors
  • pain

ASJC Scopus subject areas

  • Neuroscience(all)
  • Molecular Biology
  • Clinical Neurology
  • Developmental Biology

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