Antagonism of serotonin receptor mediated neuroendocrine and temperature responses by atypical neuroleptics in the rat

J. Frank Nash*, Herbert Y. Meltzer, Gary A. Gudelsky

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

60 Scopus citations

Abstract

The ability of atypical and typical antipsychotics to antagonize serotonin (5-HT) receptor-mediated temperature and neuroendocrine responses was tested in rats. Clozapine, melperone and setoperone, three atypical neuroleptics, blocked in a dose-dependent manner, the hyperthermic response to the 5-HT agonist, MK-212, whereas chlorpromazine and haloperidol were ineffective. The hypothermic response to the 5-HT1A agonist, 8-OH-DPAT, was unaltered by any of the atypical neuroleptics tested. Similarly, MK-212-induced corticosterone secretion was blocked in a dose-related manner by clozapine, melperone and setoperone but was relatively unaffected by either haloperidol or chlorpromazine. The increase in corticosterone secretion observed following 8-OH-DPAT administration was not attenuated by pretreatment with the atypical or typical antipsychotics tested. These data indicate that atypical neuroleptics are effective 5-HT2 but not 5-HT1A antagonists in vivo. Conversely, the typical neuroleptics, haloperidol and chlorpromazine do not block the 5-HT receptors involved in activation of the hypothalamic-pituitary-adrenal axis or thermoregulation.

Original languageEnglish (US)
Pages (from-to)463-469
Number of pages7
JournalEuropean Journal of Pharmacology
Volume151
Issue number3
DOIs
StatePublished - Jul 14 1988

Keywords

  • Antipsychotics
  • Atypical neuroleptics
  • Body temperature
  • Corticosterone
  • Serotonin antagonism

ASJC Scopus subject areas

  • Pharmacology

Fingerprint Dive into the research topics of 'Antagonism of serotonin receptor mediated neuroendocrine and temperature responses by atypical neuroleptics in the rat'. Together they form a unique fingerprint.

Cite this