Anterior and posterior pituitary disease and pregnancy

Mark E Molitch*

*Corresponding author for this work

Research output: Chapter in Book/Report/Conference proceedingChapter


Hyperprolactinemia commonly causes symptoms of galactorrhea, amenorrhea, and infertility. The differential diagnosis of hyperprolactinemia is extensive. This chapter focuses on the patient with a prolactinoma. Hemorrhage into the tumor causing headache and visual symptoms during pregnancy, however, has been reported several times. Fewer than 150 cases of Cushing's syndrome in pregnancy have been reported. Only three cases have been reported of pregnancy occurring in women with TSH-secreting tumors. Pregnancy would not expected to influence tumor size in patients with clinically nonfunctioning adenomas (CNFAs) and only two cases have been reported in which tumor enlargement during pregnancy resulted in a visual field defect. Acute fatty liver of pregnancy and other disturbances of hepatic function such as hepatitis may be associated with late onset transient diabetes insipidus (DI) of pregnancy in some patients. DI that developing postpartum may be a result of Sheehan's syndrome or lymphocytic hypophysitis.

Original languageEnglish (US)
Title of host publicationNeurological Illness in Pregnancy
Subtitle of host publicationPrinciples and Practice
PublisherWiley Blackwell
Number of pages12
ISBN (Electronic)9781118430903
ISBN (Print)9780470670439
StatePublished - Nov 30 2015


  • Amenorrhea
  • Clinically nonfunctioning adenomas
  • Cushing's syndrome
  • Galactorrhea
  • Hepatitis
  • Hyperprolactinemia
  • Pregnancy
  • Prolactinoma
  • Sheehan's syndrome

ASJC Scopus subject areas

  • Medicine(all)


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