Anthropometric correlates of C-reactive protein among indigenous Siberians

J. Josh Snodgrass, William R. Leonard, Larissa A. Tarskaia, Thomas W. McDade, Mark V. Sorensen, Vasili P. Alekseev, Vadim G. Krivoshapkin

Research output: Contribution to journalArticlepeer-review

16 Scopus citations

Abstract

C-reactive protein (CRP) is an inflammatory marker, which at low-level elevations is associated with increased cardiovascular risk. Although CRP has been extensively investigated in North American and European settings, few studies have measured CRP among non-Western groups. The present study used dried whole blood spot samples to examine high-sensitivity CRP concentrations among the Yakut (Sakha) of Siberia (85 females, 56 males; 18-58 years old). Our goals were: (1) to compare Yakut CRP concentrations with other populations; (2) to investigate sex differences; and (3) to explore anthropometric correlates of CRP. Results indicate that serum equivalent CRP concentrations are similar to those from industrializing nations, lower than US and European values, and greater than Japanese concentrations. Yakut men and women display similar CRP concentrations; however, CRP was significantly higher among men after adjustment for body fat, age, and smoking. Positive associations were documented between CRP and BMI, body fat, and central adiposity.

Original languageEnglish (US)
Pages (from-to)241-246
Number of pages6
JournalJournal of Physiological Anthropology
Volume26
Issue number2
DOIs
StatePublished - 2007

Keywords

  • Body composition
  • C-reactive protein
  • Cardiovascular risk
  • Obesity
  • Russia
  • Yakut (Sakha)

ASJC Scopus subject areas

  • Human Factors and Ergonomics
  • Physiology
  • Orthopedics and Sports Medicine
  • Anthropology
  • Public Health, Environmental and Occupational Health
  • Physiology (medical)

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