Anthropomorphic measurements and event-free survival in patients with favorable histology Wilms tumor: A report from the children's oncology group

Conrad V. Fernandez, James Anderson, Norman E. Breslow, Jeffrey S. Dome, P. E. Grundy, Elizabeth J. Perlman, Daniel M. Green

Research output: Contribution to journalArticlepeer-review

4 Scopus citations

Abstract

Purpose. We retrospectively examined the effect of body weight and body mass index (BMI) on event-free survival (EFS) of children with Wilms tumor treated on National Wilms Tumor Study-5 (NWTS-5).Patients and methods. Eligible study participants: stages I-IV favorable histology Wilms tumor with immediate nephrectomy; height and weight recorded at diagnosis, and loss of heterozygosity for chromosomes 1p and 16q assessed. Results. A total of 1,532 patients were included in the analysis. The median follow-up was 4.9 years. 493 patients were less than 2 years of age and 1039 were 2 years of age or older. In both age groups there were more patients than expected with a weight or body mass index (BMI) less than the 10% or greater than the 90%. There was no relationship of weight-for-age or BMI-for-age and EFS in univariate analyses (P = 0.28, log-rank test for both comparisons). A Cox proportional hazards model, stratified by risk/treatment groups, showed that, among patients less than 2 years of age, low or high weight-for-age was not predictive of EFS (P = 0.16). Similarly, a Cox proportional hazards model, stratified by risk/treatment groups, showed that among patients greater than 2 years of age, low or high body mass index for age was not predictive of EFS (P = 0.58). Conclusions. There was no evidence that anthropomorphic data obtained at diagnosis for patients with favorable histology stages I-IV Wilms tumor was predictive for EFS in the setting of current treatment regimens. There were more patients with lower or higher weight/BMI than expected.

Original languageEnglish (US)
Pages (from-to)254-258
Number of pages5
JournalPediatric Blood and Cancer
Volume52
Issue number2
DOIs
StatePublished - Feb 2009

Keywords

  • Body mass index
  • Prognosis
  • Wilms

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health
  • Hematology
  • Oncology

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