Anti-carcinogenic activity of d-limonene during the initiation and promotion/progression stages of dmba-induced rat mammary carcinogenesis

Charles E. Elson, Terese H. Maltzman, Jami L. Boston, Martin A. Tanner, Michael N. Gould*

*Corresponding author for this work

Research output: Contribution to journalArticle

146 Scopus citations

Abstract

d-Limonene was found to be effective in reducing the average number of rat mammary carcinomas that developed in 7,12-dimeihylbenz[a]anthracene-treated rats when the terpene was fed during the initiation or during the promotion/progression stage of carcinogenesis. The time to the appearance of the first tumor was extended only when d-limonene was fed during the initiation stage. These effects could not be attributed to changes in mammary-relevant endocrine functions.

Original languageEnglish (US)
Pages (from-to)331-332
Number of pages2
JournalCarcinogenesis
Volume9
Issue number2
DOIs
StatePublished - Feb 1 1988

ASJC Scopus subject areas

  • Cancer Research

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