Anti-CD4 antibodies are associated with HIV-1 seroconversion and may be detectable before Anti-HIV-1 antibodies

P. Keiser, S. Keay*, S. Wasserman, W. Wecksler, A. Saah, J. Palenicek, J. Margolick, J. McArthur, H. Fazadegan, H. Armenian, N. Graham, J. Phair, J. Chmiel, K. Sheridan, B. Cohen, S. Wolinsky, R. Detels, B. Vischer, J. Fahey

*Corresponding author for this work

Research output: Contribution to journalArticle

13 Scopus citations

Abstract

We examined the sera from 14 HIV-1 seroconverters for the presence of autoantibodies against CD4. Anti-CD4 antibodies were detected in the serum of 11 of 13 HIV-1-infected persons at the time of HIV-1 seroconversion. In 6 of 14 persons from whom a serum was obtained prior to HIV-1 seroconversion, anti-CD4 antibodies were found 90 to 540 days before antibodies to HIV-1 were detectable. In comparison, anti-CD4 antibodies were present in only 7 serum samples from 62 HIV-1 seronegative individuals, including 50 from a seronegative homosexual male cohort. These results suggest that anti-CD4 antibodies are generated in response to early HIV-1 infection and possibly could be used as a marker for HIV-1 infection in some infected persons who are seronegative for HIV-1.

Original languageEnglish
Pages (from-to)1919-1927
Number of pages9
JournalAIDS Research and Human Retroviruses
Volume8
Issue number11
StatePublished - 1992

ASJC Scopus subject areas

  • Immunology
  • Virology

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    Keiser, P., Keay, S., Wasserman, S., Wecksler, W., Saah, A., Palenicek, J., Margolick, J., McArthur, J., Fazadegan, H., Armenian, H., Graham, N., Phair, J., Chmiel, J., Sheridan, K., Cohen, B., Wolinsky, S., Detels, R., Vischer, B., & Fahey, J. (1992). Anti-CD4 antibodies are associated with HIV-1 seroconversion and may be detectable before Anti-HIV-1 antibodies. AIDS Research and Human Retroviruses, 8(11), 1919-1927.