Anti-contamination device for cryogenic soft X-ray diffraction microscopy

Xiaojing Huang*, Huijie Miao, Johanna Nelson, Joshua Turner, Jan Steinbrener, David Shapiro, Janos Kirz, Chris Jacobsen

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

5 Scopus citations


Cryogenic microscopy allows one to view frozen hydrated biological and soft matter specimens with good structural preservation and a high degree of stability against radiation damage. We describe a liquid nitrogen-cooled anti-contamination device for cryogenic X-ray diffraction microscopy. The anti-contaminator greatly reduces the buildup of ice layers on the specimen due to condensation of residual water vapor in the experimental vacuum chamber. We show by coherent X-ray diffraction measurements that this leads to fivefold reduction of background scattering, which is important for far-field X-ray diffraction microscopy of biological specimens.

Original languageEnglish (US)
Pages (from-to)171-175
Number of pages5
JournalNuclear Instruments and Methods in Physics Research, Section A: Accelerators, Spectrometers, Detectors and Associated Equipment
Issue number1
StatePublished - May 11 2011


  • Anti-contamination
  • Cryogenic X-ray microscopy
  • Diffraction microscopy
  • X-ray Imaging

ASJC Scopus subject areas

  • Nuclear and High Energy Physics
  • Instrumentation


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