Anti-dementia drugs and hippocampal-dependent memory in rodents

Carla M. Yuede, Hongxin Dong, John G. Csernansky*

*Corresponding author for this work

Research output: Contribution to journalReview article

47 Scopus citations

Abstract

Abnormalities in hippocampal structure and function are characteristics of early Alzheimer's disease (AD). Behavioral tests measuring hippocampal-dependent memory in rodents are often used to evaluate novel treatments for AD and other dementias. In this study, we review the effects of drugs marketed for the treatment of AD, such as the acetylcholinesterase inhibitors, donepezil, rivastigmine, galantamine and the N-methyl-D-aspartic acid antagonist, memantine, in rodent models of memory impairment. We also briefly describe the effects of novel treatments for cognitive impairment in rodent models of memory impairment, and discuss issues concerning the selection of the animal model and behavioral tests. Suggestions for future research are offered.

Original languageEnglish (US)
Pages (from-to)347-363
Number of pages17
JournalBehavioural Pharmacology
Volume18
Issue number5-6
DOIs
StatePublished - Sep 1 2007

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Keywords

  • Anticholinesterases
  • Dementia
  • Hippocampus
  • Memantine
  • Memory
  • Mouse
  • Rat

ASJC Scopus subject areas

  • Pharmacology
  • Psychiatry and Mental health

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