Anti-dopaminergic and anti-muscarinic effects of dibenzodiazepines - Relationship to drug induced parkinsonism

R. J. Miller*, C. R. Hiley

*Corresponding author for this work

Research output: Contribution to journalArticle

25 Scopus citations

Abstract

1. The anti-dopaminergic effects of several dibenzodiazepines were examined on the dopaminestimulated adenylate cyclase in rat striatal homogenates. The "cis" isomer of clozapine, HF-2046, was the most potent in this respect and perlapine, which is devoid of neuroleptic activity, was the weakest. 2. The anti-muscarinic effects of the same compounds were measured by using the muscarinic affinity label 3H-propylbenzilylcholine mustard. HF-2046 was the most potent and loxapine the least potent of the drugs used. 3. The anti-dopaminrgic effects of the drugs correlate well with neuroleptic but not with extrapyramidal effects. The anti-dopaminergic/anti-muscarinic ratio, however, correlates well with extrapyramidal rather than neuroleptic effects.

Original languageEnglish (US)
Pages (from-to)289-293
Number of pages5
JournalNaunyn-Schmiedeberg's Archives of Pharmacology
Volume292
Issue number3
DOIs
StatePublished - Jan 1 1976

Keywords

  • Clozapine
  • Dibenzodiazepines
  • Dopamine
  • Muscarinic receptors
  • Parkinsonism

ASJC Scopus subject areas

  • Pharmacology

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