Anti-HER2/neu therapy in DCIS

Amelia Tower; Ruta D. Rao; Kalliopi P. Siziopikou; Melody A. Cobleigh; Thomas B. Julian

doi:10.1007/978-1-4939-2035-8_10

Anti-HER2/neu therapy in DCIS

Amelia Tower, Ruta D. Rao, Kalliopi P. Siziopikou, Melody A. Cobleigh, Thomas B. Julian^*

^*Corresponding author for this work

Pathology

Research output: Chapter in Book/Report/Conference proceeding › Chapter

Abstract

Ductal carcinoma in situ (DCIS) is a heterogeneous form of preinvasive breast cancer, with subtypes that are comparable to those of invasive disease. Targeted molecular therapies have improved outcomes for patients with invasive breast cancer, and we have parallel opportunities for advances in personalized treatment of DCIS. Early work has demonstrated synergy between human epidermal growth factor receptor (HER)2-targeted therapy and radiotherapy. Anti-HER2 therapy may also induce an immune response. This chapter addresses the history of research regarding HER2 expression in DCIS as well as ongoing clinical trials that address whether HER2-targeted therapy will improve patient outcomes in DCIS.

Original language	English (US)
Title of host publication	Ductal Carcinoma in Situ and Microinvasive/Borderline Breast Cancer
Publisher	Springer New York
Pages	99-108
Number of pages	10
ISBN (Electronic)	9781493920358
ISBN (Print)	9781493920341
DOIs	https://doi.org/10.1007/978-1-4939-2035-8_10
State	Published - Jan 1 2015

Keywords

Ductal carcinoma in situ
HER2/neu
Radiotherapy
Trastuzumab

ASJC Scopus subject areas

Medicine(all)

Access to Document

10.1007/978-1-4939-2035-8_10

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abstract = "Ductal carcinoma in situ (DCIS) is a heterogeneous form of preinvasive breast cancer, with subtypes that are comparable to those of invasive disease. Targeted molecular therapies have improved outcomes for patients with invasive breast cancer, and we have parallel opportunities for advances in personalized treatment of DCIS. Early work has demonstrated synergy between human epidermal growth factor receptor (HER)2-targeted therapy and radiotherapy. Anti-HER2 therapy may also induce an immune response. This chapter addresses the history of research regarding HER2 expression in DCIS as well as ongoing clinical trials that address whether HER2-targeted therapy will improve patient outcomes in DCIS.",

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AU - Julian, Thomas B.

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