Anti-Infective Prophylaxis, Immunization and Prevention of Recurrent Infectious Complications in Long-Term Survivors

John P. Galvin*, Jayesh Mehta

*Corresponding author for this work

Research output: Chapter in Book/Report/Conference proceedingChapter

Abstract

After allogeneic hematopoietic stem cell transplantation (HSCT), immune reconstitution occurs gradually. The risk for infections and specific pathogens during this period is related to the extent and type of immune deficiency. The presence of chronic graft-versus-host disease (GVHD) increases the risk for infections with encapsulated bacteria, such as Streptococcus pneumoniae or Haemophilus influenzae. Persistent defects in cell-mediated and humoral immunity in the months to years following HSCT increase the risk for viral infections (e.g., cytomegalovirus and respiratory viruses). Long-term HSCT survivors also have an increased risk for fungal pneumonia (e.g., Aspergillus spp., Pneumocystis jirovecii). Therefore, prophylaxis and preemptive treatment of opportunistic infections is of critical importance in the setting of chronic GVHD and ongoing immunosuppressive therapy to prevent morbidity and mortality. As the immune system recovers, it is also important to re-immunize against childhood illnesses and to receive the seasonal influenza vaccine.

Original languageEnglish (US)
Title of host publicationBlood and Marrow Transplantation Long Term Management
Subtitle of host publicationPrevention and Complications
PublisherWiley Blackwell
Pages106-115
Number of pages10
ISBN (Electronic)9781118473306
ISBN (Print)9781118473405
DOIs
StatePublished - Sep 9 2013

Keywords

  • Allogeneic
  • Graft-versus-host disease
  • Hematopoietic stem cell transplant
  • Late infection

ASJC Scopus subject areas

  • Medicine(all)

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  • Cite this

    Galvin, J. P., & Mehta, J. (2013). Anti-Infective Prophylaxis, Immunization and Prevention of Recurrent Infectious Complications in Long-Term Survivors. In Blood and Marrow Transplantation Long Term Management: Prevention and Complications (pp. 106-115). Wiley Blackwell. https://doi.org/10.1002/9781118473306.ch11