Anti-Inflammatory and Anti-Thrombogenic Properties of Arterial Elastic Laminae

Jeremy Goldman*, Shu Q. Liu*, Brandon J. Tefft*

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review

1 Scopus citations

Abstract

Elastic laminae, an elastin-based, layered extracellular matrix structure in the media of arteries, can inhibit leukocyte adhesion and vascular smooth muscle cell proliferation and migration, exhibiting anti-inflammatory and anti-thrombogenic properties. These properties prevent inflammatory and thrombogenic activities in the arterial media, constituting a mechanism for the maintenance of the structural integrity of the arterial wall in vascular disorders. The biological basis for these properties is the elastin-induced activation of inhibitory signaling pathways, involving the inhibitory cell receptor signal regulatory protein α (SIRPα) and Src homology 2 domain-containing protein tyrosine phosphatase 1 (SHP1). The activation of these molecules causes deactivation of cell adhesion- and proliferation-regulatory signaling mechanisms. Given such anti-inflammatory and anti-thrombogenic properties, elastic laminae and elastin-based materials have potential for use in vascular reconstruction.

Original languageEnglish (US)
Article number424
JournalBioengineering
Volume10
Issue number4
DOIs
StatePublished - Apr 2023

Keywords

  • arterial reconstruction
  • elastin
  • inflammation
  • intimal hyperplasia
  • thrombosis

ASJC Scopus subject areas

  • Bioengineering

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