Anti-inflammatory properties of amniotic membrane patch following pericardiectomy for constrictive pericarditis

Katherine M. Marsh, Alice S. Ferng, Tia Pilikian, Ankit A. Desai, Ryan Avery, Mark Friedman, Isabel Oliva, Clint Jokerst, David Schipper, Zain Khalpey*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

16 Scopus citations


Background: Since constrictive pericarditis is most often idiopathic and the pathophysiology remains largely unknown, both the diagnosis and the treatment can be challenging. However, by definition, inflammatory processes are central to this disease process. Amniotic membrane patches have been shown to possess anti-inflammatory properties and are believed to be immune privileged. Due to these properties, amniotic membrane patches were applied intraoperatively in a complicated patient presenting with constrictive pericarditis. Case presentation: A patient with a history of multiple cardiac surgeries presented with marked fatigue, worsening dyspnea and sinus tachycardia. He was found to have constrictive physiology during cardiac catheterization, with cardiac MRI demonstrating hepatic vein dilatation, atrial enlargement and ventricular narrowing. After amniotic membrane patch treatment and pericardiectomy, post-operative cardiac MRI failed to demonstrate any appreciable pericardial effusion or inflammation, with no increased T2 signal that would suggest edema. Conclusions: Given the positive results seen in this complex patient, we suggest continued research into the beneficial properties of amniotic membrane patches in cardiac surgery.

Original languageEnglish (US)
Article number6
JournalJournal of Cardiothoracic Surgery
Issue number1
StatePublished - Jan 26 2017


  • Amniotic membrane patch
  • Constrictive pericarditis
  • Orthotopic heart transplant

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine
  • Pulmonary and Respiratory Medicine
  • Surgery


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