Anti-muscarinic properties of neuroleptics and drug-induced Parkinsonism

Richard J. Miller*, C. Robin Hiley

*Corresponding author for this work

Research output: Contribution to journalArticle

294 Scopus citations

Abstract

ONE unifying hypothesis of the behavioural effects produced by neuroleptic drugs is that they act by blocking dopamine receptors in the central nervous system1-3. Neuroleptic drugs produce increases in dopamine turnover4, increase accumulation of its metabolites5, antagonise amphetamine induced behaviour in man and animals6 and block the stimulating effects of dopamine on cyclic AMP production in homogenates of rat brain striatum or mesolimbic nuclei7-9.

Original languageEnglish (US)
Pages (from-to)596-597
Number of pages2
JournalNature
Volume248
Issue number5449
DOIs
StatePublished - Dec 1 1974

ASJC Scopus subject areas

  • General

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