Anti-neuroblastoma monoclonal antibodies which do not bind to bone marrow cells.

C. N. Frantz*, R. E. Duerst, D. H. Ryan, N. L. Gelsomino, L. S. Constine, P. K. Gregory

*Corresponding author for this work

Research output: Contribution to journalArticle

5 Scopus citations

Abstract

Three previously unreported mouse monoclonal antibodies are described. All three bind to cultured human neuroblastoma cells from six of six cell lines, but do not detectably bind to human bone marrow cells. The two IgG2a monoclonal antibodies bind to greater than 98% of the cultured cells from each cell line, bind to six of six human neuroblastoma tumors by immunoperoxidase histochemistry, and are cytotoxic with complement to cultured human neuroblastoma cells but not to human bone marrow granulocyte-macrophage colony-forming cells.

Original languageEnglish (US)
Pages (from-to)485-499
Number of pages15
JournalProgress in Clinical and Biological Research
Volume175
StatePublished - Jan 1 1985

ASJC Scopus subject areas

  • Medicine(all)

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    Frantz, C. N., Duerst, R. E., Ryan, D. H., Gelsomino, N. L., Constine, L. S., & Gregory, P. K. (1985). Anti-neuroblastoma monoclonal antibodies which do not bind to bone marrow cells. Progress in Clinical and Biological Research, 175, 485-499.