TY - JOUR
T1 - Antibacterial nicotinamide adenine dinucleotide synthetase inhibitors
T2 - Amide- and ether-linked tethered dimers with α-amino acid end groups
AU - Velu, Sadanandan E.
AU - Mou, Liyuan
AU - Luan, Chi Hao
AU - Yang, Zhengrong W.
AU - DeLucas, Lawrence J.
AU - Brouillette, Christie G.
AU - Brouillette, Wayne J.
PY - 2007/5/31
Y1 - 2007/5/31
N2 - Tethered dimers incorporating natural α-amino acid end groups were synthesized, including examples in which the previously reported esterase-sensitive ester linker was replaced with more stable amide or ether linkers. These compounds remained effective both as inhibitors of NAD synthetase and as potent antibacterial agents for Gram-positive strains. Studies on nonspecific effects, including detergent properties and promiscuous inhibition, suggested little contribution to observed activities.
AB - Tethered dimers incorporating natural α-amino acid end groups were synthesized, including examples in which the previously reported esterase-sensitive ester linker was replaced with more stable amide or ether linkers. These compounds remained effective both as inhibitors of NAD synthetase and as potent antibacterial agents for Gram-positive strains. Studies on nonspecific effects, including detergent properties and promiscuous inhibition, suggested little contribution to observed activities.
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U2 - 10.1021/jm061349l
DO - 10.1021/jm061349l
M3 - Article
C2 - 17489580
AN - SCOPUS:34250161577
VL - 50
SP - 2612
EP - 2621
JO - Journal of Medicinal Chemistry
JF - Journal of Medicinal Chemistry
SN - 0022-2623
IS - 11
ER -