Antibacterial nicotinamide adenine dinucleotide synthetase inhibitors: Amide- and ether-linked tethered dimers with α-amino acid end groups

Sadanandan E. Velu, Liyuan Mou, Chi Hao Luan, Zhengrong W. Yang, Lawrence J. DeLucas, Christie G. Brouillette, Wayne J. Brouillette*

*Corresponding author for this work

Research output: Contribution to journalArticle

16 Scopus citations

Abstract

Tethered dimers incorporating natural α-amino acid end groups were synthesized, including examples in which the previously reported esterase-sensitive ester linker was replaced with more stable amide or ether linkers. These compounds remained effective both as inhibitors of NAD synthetase and as potent antibacterial agents for Gram-positive strains. Studies on nonspecific effects, including detergent properties and promiscuous inhibition, suggested little contribution to observed activities.

Original languageEnglish (US)
Pages (from-to)2612-2621
Number of pages10
JournalJournal of Medicinal Chemistry
Volume50
Issue number11
DOIs
StatePublished - May 31 2007

ASJC Scopus subject areas

  • Molecular Medicine
  • Drug Discovery

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