Antibiotic stewardship in the intensive care unit: An official American thoracic society workshop report in collaboration with the aacn, chest, cdc, and sccm

Richard G. Wunderink, Arjun Srinivasan, Philip S. Barie, Jean Chastre, Charles S. Dela Cruz, Ivor S. Douglas, Margaret Ecklund, Scott E. Evans, Scott R. Evans, Anthony T. Gerlach, Lauri A. Hicks, Michael Howell, Melissa L. Hutchinson, Robert C. Hyzy, Sandra L. Kane-Gill, Erika D. Lease, Mark L. Metersky, Nancy Munro, Michael S. Niederman, Marcos I. RestrepoCurtis N. Sessler, Steven Q. Simpson, Sandra M. Swoboda, Christina Vazquez Guillamet, Grant W. Waterer, Curtis Weiss

Research output: Contribution to journalArticle

Abstract

Intensive care units (ICUs) are an appropriate focus of antibiotic stewardship program efforts because a large proportion of any hospital’s use of parenteral antibiotics, especially broad-spectrum, occurs in the ICU. Given the importance of antibiotic stewardship for critically ill patients and the importance of critical care practitioners as the front line for antibiotic stewardship, a workshop was convened to specifically address barriers to antibiotic stewardship in the ICU and discuss tactics to overcome these. The working definition of antibiotic stewardship is “the right drug at the right time and the right dose for the right bug for the right duration.” A major emphasis was that antibiotic stewardship should be a core competency of critical care clinicians. Fear of pathogens that are not covered by empirical antibiotics is a major driver of excessively broad-spectrum therapy in critically ill patients. Better diagnostics and outcome data can address this fear and expand efforts to narrow or shorten therapy. Greater awareness of the substantial adverse effects of antibiotics should be emphasized and is an important counterargument to broad-spectrum therapy in individual low-risk patients. Optimal antibiotic stewardship should not focus solely on reducing antibiotic use or ensuring compliance with guidelines. Instead, it should enhance care both for individual patients (by improving and individualizing their choice of antibiotic) and for the ICU population as a whole. Opportunities for antibiotic stewardship in common ICU infections, including community- and hospital-acquired pneumonia and sepsis, are discussed. Intensivists can partner with antibiotic stewardship programs to address barriers and improve patient care.

Original languageEnglish (US)
Pages (from-to)531-540
Number of pages10
JournalAnnals of the American Thoracic Society
Volume17
Issue number5
DOIs
StatePublished - May 2020

Keywords

  • Antibiotic resistance
  • Antibiotic stewardship
  • Pneumonia
  • Sepsis

ASJC Scopus subject areas

  • Pulmonary and Respiratory Medicine

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    Wunderink, R. G., Srinivasan, A., Barie, P. S., Chastre, J., Dela Cruz, C. S., Douglas, I. S., Ecklund, M., Evans, S. E., Evans, S. R., Gerlach, A. T., Hicks, L. A., Howell, M., Hutchinson, M. L., Hyzy, R. C., Kane-Gill, S. L., Lease, E. D., Metersky, M. L., Munro, N., Niederman, M. S., ... Weiss, C. (2020). Antibiotic stewardship in the intensive care unit: An official American thoracic society workshop report in collaboration with the aacn, chest, cdc, and sccm. Annals of the American Thoracic Society, 17(5), 531-540. https://doi.org/10.1513/AnnalsATS.202003-188ST