Antibodies to Toluene Düsocyanate in Patients with and without Dialysis Anaphylaxis

Leslie C. Grammer; Kathleen E. Harris; Martha A. Shaughnessy; Jerry Dolovich; Roy Patterson; Susan Evans

doi:10.1111/j.1525-1594.1991.tb00752.x

Antibodies to Toluene Düsocyanate in Patients with and without Dialysis Anaphylaxis

Leslie C. Grammer^*, Kathleen E. Harris, Martha A. Shaughnessy, Jerry Dolovich, Roy Patterson, Susan Evans

^*Corresponding author for this work

Medicine, Allergy Division

Research output: Contribution to journal › Article › peer-review

2 Scopus citations

Abstract

Abstract: In a majority of patients with anaphylaxis to dialysis, ethylene oxide has been identified as an etiologic agent. In a significant minority of patients sustaining such reactions, the antigen remains unidentified. Conflicting results have been published with regard to isocyanates as a possible antigen. The authors studied 19 hemodialysis patients with anaphylaxis in whom IgE against ethylene oxide–human serum albumin (ETO–HSA) was not identified (Group 1) and 25 peritoneal dialysis patients without anaphylaxis (Group 2). IgE against toluene diisocyanatehuman serum albumin (TDI–HSA) was found in one patient in Group 1, and a similar incidence of IgG against TDI–HSA in Group I (16%) and Group 2 (12%) was noted. The results do not suggest that IgE against TDIHSA is an important cause of dialysis anaphylaxis.

Original language	English (US)
Pages (from-to)	2-4
Number of pages	3
Journal	Artificial organs
Volume	15
Issue number	1
DOIs	https://doi.org/10.1111/j.1525-1594.1991.tb00752.x
State	Published - Feb 1991

Keywords

Antibodies
Dialysis
IgE
IgG
Toluene diisocyanate

ASJC Scopus subject areas

Bioengineering
Medicine (miscellaneous)
Biomaterials
Biomedical Engineering

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10.1111/j.1525-1594.1991.tb00752.x

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@article{39eb6a261f954fada6d92a68bd427d03,

title = "Antibodies to Toluene D{\"u}socyanate in Patients with and without Dialysis Anaphylaxis",

abstract = "Abstract: In a majority of patients with anaphylaxis to dialysis, ethylene oxide has been identified as an etiologic agent. In a significant minority of patients sustaining such reactions, the antigen remains unidentified. Conflicting results have been published with regard to isocyanates as a possible antigen. The authors studied 19 hemodialysis patients with anaphylaxis in whom IgE against ethylene oxide–human serum albumin (ETO–HSA) was not identified (Group 1) and 25 peritoneal dialysis patients without anaphylaxis (Group 2). IgE against toluene diisocyanatehuman serum albumin (TDI–HSA) was found in one patient in Group 1, and a similar incidence of IgG against TDI–HSA in Group I (16%) and Group 2 (12%) was noted. The results do not suggest that IgE against TDIHSA is an important cause of dialysis anaphylaxis.",

keywords = "Antibodies, Dialysis, IgE, IgG, Toluene diisocyanate",

author = "Grammer, {Leslie C.} and Harris, {Kathleen E.} and Shaughnessy, {Martha A.} and Jerry Dolovich and Roy Patterson and Susan Evans",

year = "1991",

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doi = "10.1111/j.1525-1594.1991.tb00752.x",

language = "English (US)",

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TY - JOUR

T1 - Antibodies to Toluene Düsocyanate in Patients with and without Dialysis Anaphylaxis

AU - Grammer, Leslie C.

AU - Harris, Kathleen E.

AU - Shaughnessy, Martha A.

AU - Dolovich, Jerry

AU - Patterson, Roy

AU - Evans, Susan

PY - 1991/2

Y1 - 1991/2

N2 - Abstract: In a majority of patients with anaphylaxis to dialysis, ethylene oxide has been identified as an etiologic agent. In a significant minority of patients sustaining such reactions, the antigen remains unidentified. Conflicting results have been published with regard to isocyanates as a possible antigen. The authors studied 19 hemodialysis patients with anaphylaxis in whom IgE against ethylene oxide–human serum albumin (ETO–HSA) was not identified (Group 1) and 25 peritoneal dialysis patients without anaphylaxis (Group 2). IgE against toluene diisocyanatehuman serum albumin (TDI–HSA) was found in one patient in Group 1, and a similar incidence of IgG against TDI–HSA in Group I (16%) and Group 2 (12%) was noted. The results do not suggest that IgE against TDIHSA is an important cause of dialysis anaphylaxis.

AB - Abstract: In a majority of patients with anaphylaxis to dialysis, ethylene oxide has been identified as an etiologic agent. In a significant minority of patients sustaining such reactions, the antigen remains unidentified. Conflicting results have been published with regard to isocyanates as a possible antigen. The authors studied 19 hemodialysis patients with anaphylaxis in whom IgE against ethylene oxide–human serum albumin (ETO–HSA) was not identified (Group 1) and 25 peritoneal dialysis patients without anaphylaxis (Group 2). IgE against toluene diisocyanatehuman serum albumin (TDI–HSA) was found in one patient in Group 1, and a similar incidence of IgG against TDI–HSA in Group I (16%) and Group 2 (12%) was noted. The results do not suggest that IgE against TDIHSA is an important cause of dialysis anaphylaxis.

KW - Antibodies

KW - Dialysis

KW - IgE

KW - IgG

KW - Toluene diisocyanate

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Antibodies to Toluene Düsocyanate in Patients with and without Dialysis Anaphylaxis

Abstract

Keywords

ASJC Scopus subject areas

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