Antibody escape and global spread of SARS-CoV-2 lineage A.27

Tamara Kaleta, Lisa Kern, Samuel Leandro Hong, Martin Hölzer, Georg Kochs, Julius Beer, Daniel Schnepf, Martin Schwemmle, Nena Bollen, Philipp Kolb, Magdalena Huber, Svenja Ulferts, Sebastian Weigang, Gytis Dudas, Alice Wittig, Lena Jaki, Abdou Padane, Adamou Lagare, Mounerou Salou, Egon Anderson OzerNdodo Nnaemeka, John Kofi Odoom, Robert Rutayisire, Alia Benkahla, Chantal Akoua-Koffi, Abdoul Salam Ouedraogo, Etienne Simon-Lorière, Vincent Enouf, Stefan Kröger, Sébastien Calvignac-Spencer, Guy Baele, Marcus Panning*, Jonas Fuchs

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

Abstract

In spring 2021, an increasing number of infections was observed caused by the hitherto rarely described SARS-CoV-2 variant A.27 in south-west Germany. From December 2020 to June 2021 this lineage has been detected in 31 countries. Phylogeographic analyses of A.27 sequences obtained from national and international databases reveal a global spread of this lineage through multiple introductions from its inferred origin in Western Africa. Variant A.27 is characterized by a mutational pattern in the spike gene that includes the L18F, L452R and N501Y spike amino acid substitutions found in various variants of concern but lacks the globally dominant D614G. Neutralization assays demonstrate an escape of A.27 from convalescent and vaccine-elicited antibody-mediated immunity. Moreover, the therapeutic monoclonal antibody Bamlanivimab and partially the REGN-COV2 cocktail fail to block infection by A.27. Our data emphasize the need for continued global monitoring of novel lineages because of the independent evolution of new escape mutations.

Original languageEnglish (US)
Article number1152
JournalNature communications
Volume13
Issue number1
DOIs
StatePublished - Dec 2022

ASJC Scopus subject areas

  • Chemistry(all)
  • Biochemistry, Genetics and Molecular Biology(all)
  • Physics and Astronomy(all)

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