Antibody escape and global spread of SARS-CoV-2 lineage A.27

Tamara Kaleta; Lisa Kern; Samuel Leandro Hong; Martin Hölzer; Georg Kochs; Julius Beer; Daniel Schnepf; Martin Schwemmle; Nena Bollen; Philipp Kolb; Magdalena Huber; Svenja Ulferts; Sebastian Weigang; Gytis Dudas; Alice Wittig; Lena Jaki; Abdou Padane; Adamou Lagare; Mounerou Salou; Egon Anderson Ozer; Ndodo Nnaemeka; John Kofi Odoom; Robert Rutayisire; Alia Benkahla; Chantal Akoua-Koffi; Abdoul Salam Ouedraogo; Etienne Simon-Lorière; Vincent Enouf; Stefan Kröger; Sébastien Calvignac-Spencer; Guy Baele; Marcus Panning; Jonas Fuchs

doi:10.1038/s41467-022-28766-y

Antibody escape and global spread of SARS-CoV-2 lineage A.27

Tamara Kaleta, Lisa Kern, Samuel Leandro Hong, Martin Hölzer, Georg Kochs, Julius Beer, Daniel Schnepf, Martin Schwemmle, Nena Bollen, Philipp Kolb, Magdalena Huber, Svenja Ulferts, Sebastian Weigang, Gytis Dudas, Alice Wittig, Lena Jaki, Abdou Padane, Adamou Lagare, Mounerou Salou, Egon Anderson OzerNdodo Nnaemeka, John Kofi Odoom, Robert Rutayisire, Alia Benkahla, Chantal Akoua-Koffi, Abdoul Salam Ouedraogo, Etienne Simon-Lorière, Vincent Enouf, Stefan Kröger, Sébastien Calvignac-Spencer, Guy Baele, Marcus Panning^*, Jonas Fuchs^*

^*Corresponding author for this work

Medicine, Infectious Diseases Division

Research output: Contribution to journal › Article › peer-review

9 Scopus citations

Abstract

In spring 2021, an increasing number of infections was observed caused by the hitherto rarely described SARS-CoV-2 variant A.27 in south-west Germany. From December 2020 to June 2021 this lineage has been detected in 31 countries. Phylogeographic analyses of A.27 sequences obtained from national and international databases reveal a global spread of this lineage through multiple introductions from its inferred origin in Western Africa. Variant A.27 is characterized by a mutational pattern in the spike gene that includes the L18F, L452R and N501Y spike amino acid substitutions found in various variants of concern but lacks the globally dominant D614G. Neutralization assays demonstrate an escape of A.27 from convalescent and vaccine-elicited antibody-mediated immunity. Moreover, the therapeutic monoclonal antibody Bamlanivimab and partially the REGN-COV2 cocktail fail to block infection by A.27. Our data emphasize the need for continued global monitoring of novel lineages because of the independent evolution of new escape mutations.

Original language	English (US)
Article number	1152
Journal	Nature communications
Volume	13
Issue number	1
DOIs	https://doi.org/10.1038/s41467-022-28766-y
State	Published - Dec 2022

ASJC Scopus subject areas

General
Physics and Astronomy(all)
Chemistry(all)
Biochemistry, Genetics and Molecular Biology(all)

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10.1038/s41467-022-28766-y

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Kaleta, T., Kern, L., Hong, S. L., Hölzer, M., Kochs, G., Beer, J., Schnepf, D., Schwemmle, M., Bollen, N., Kolb, P., Huber, M., Ulferts, S., Weigang, S., Dudas, G., Wittig, A., Jaki, L., Padane, A., Lagare, A., Salou, M., ... Fuchs, J. (2022). Antibody escape and global spread of SARS-CoV-2 lineage A.27. Nature communications, 13(1), [1152]. https://doi.org/10.1038/s41467-022-28766-y

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title = "Antibody escape and global spread of SARS-CoV-2 lineage A.27",

abstract = "In spring 2021, an increasing number of infections was observed caused by the hitherto rarely described SARS-CoV-2 variant A.27 in south-west Germany. From December 2020 to June 2021 this lineage has been detected in 31 countries. Phylogeographic analyses of A.27 sequences obtained from national and international databases reveal a global spread of this lineage through multiple introductions from its inferred origin in Western Africa. Variant A.27 is characterized by a mutational pattern in the spike gene that includes the L18F, L452R and N501Y spike amino acid substitutions found in various variants of concern but lacks the globally dominant D614G. Neutralization assays demonstrate an escape of A.27 from convalescent and vaccine-elicited antibody-mediated immunity. Moreover, the therapeutic monoclonal antibody Bamlanivimab and partially the REGN-COV2 cocktail fail to block infection by A.27. Our data emphasize the need for continued global monitoring of novel lineages because of the independent evolution of new escape mutations.",

author = "Tamara Kaleta and Lisa Kern and Hong, {Samuel Leandro} and Martin H{\"o}lzer and Georg Kochs and Julius Beer and Daniel Schnepf and Martin Schwemmle and Nena Bollen and Philipp Kolb and Magdalena Huber and Svenja Ulferts and Sebastian Weigang and Gytis Dudas and Alice Wittig and Lena Jaki and Abdou Padane and Adamou Lagare and Mounerou Salou and Ozer, {Egon Anderson} and Ndodo Nnaemeka and Odoom, {John Kofi} and Robert Rutayisire and Alia Benkahla and Chantal Akoua-Koffi and Ouedraogo, {Abdoul Salam} and Etienne Simon-Lori{\`e}re and Vincent Enouf and Stefan Kr{\"o}ger and S{\'e}bastien Calvignac-Spencer and Guy Baele and Marcus Panning and Jonas Fuchs",

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year = "2022",

month = dec,

doi = "10.1038/s41467-022-28766-y",

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Kaleta, T, Kern, L, Hong, SL, Hölzer, M, Kochs, G, Beer, J, Schnepf, D, Schwemmle, M, Bollen, N, Kolb, P, Huber, M, Ulferts, S, Weigang, S, Dudas, G, Wittig, A, Jaki, L, Padane, A, Lagare, A, Salou, M, Ozer, EA, Nnaemeka, N, Odoom, JK, Rutayisire, R, Benkahla, A, Akoua-Koffi, C, Ouedraogo, AS, Simon-Lorière, E, Enouf, V, Kröger, S, Calvignac-Spencer, S, Baele, G, Panning, M & Fuchs, J 2022, 'Antibody escape and global spread of SARS-CoV-2 lineage A.27', Nature communications, vol. 13, no. 1, 1152. https://doi.org/10.1038/s41467-022-28766-y

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T1 - Antibody escape and global spread of SARS-CoV-2 lineage A.27

AU - Kaleta, Tamara

AU - Kern, Lisa

AU - Hong, Samuel Leandro

AU - Hölzer, Martin

AU - Kochs, Georg

AU - Beer, Julius

AU - Schnepf, Daniel

AU - Schwemmle, Martin

AU - Bollen, Nena

AU - Kolb, Philipp

AU - Huber, Magdalena

AU - Ulferts, Svenja

AU - Weigang, Sebastian

AU - Dudas, Gytis

AU - Wittig, Alice

AU - Jaki, Lena

AU - Padane, Abdou

AU - Lagare, Adamou

AU - Salou, Mounerou

AU - Ozer, Egon Anderson

AU - Nnaemeka, Ndodo

AU - Odoom, John Kofi

AU - Rutayisire, Robert

AU - Benkahla, Alia

AU - Akoua-Koffi, Chantal

AU - Ouedraogo, Abdoul Salam

AU - Simon-Lorière, Etienne

AU - Enouf, Vincent

AU - Kröger, Stefan

AU - Calvignac-Spencer, Sébastien

AU - Baele, Guy

AU - Panning, Marcus

AU - Fuchs, Jonas

PY - 2022/12

Y1 - 2022/12

N2 - In spring 2021, an increasing number of infections was observed caused by the hitherto rarely described SARS-CoV-2 variant A.27 in south-west Germany. From December 2020 to June 2021 this lineage has been detected in 31 countries. Phylogeographic analyses of A.27 sequences obtained from national and international databases reveal a global spread of this lineage through multiple introductions from its inferred origin in Western Africa. Variant A.27 is characterized by a mutational pattern in the spike gene that includes the L18F, L452R and N501Y spike amino acid substitutions found in various variants of concern but lacks the globally dominant D614G. Neutralization assays demonstrate an escape of A.27 from convalescent and vaccine-elicited antibody-mediated immunity. Moreover, the therapeutic monoclonal antibody Bamlanivimab and partially the REGN-COV2 cocktail fail to block infection by A.27. Our data emphasize the need for continued global monitoring of novel lineages because of the independent evolution of new escape mutations.

AB - In spring 2021, an increasing number of infections was observed caused by the hitherto rarely described SARS-CoV-2 variant A.27 in south-west Germany. From December 2020 to June 2021 this lineage has been detected in 31 countries. Phylogeographic analyses of A.27 sequences obtained from national and international databases reveal a global spread of this lineage through multiple introductions from its inferred origin in Western Africa. Variant A.27 is characterized by a mutational pattern in the spike gene that includes the L18F, L452R and N501Y spike amino acid substitutions found in various variants of concern but lacks the globally dominant D614G. Neutralization assays demonstrate an escape of A.27 from convalescent and vaccine-elicited antibody-mediated immunity. Moreover, the therapeutic monoclonal antibody Bamlanivimab and partially the REGN-COV2 cocktail fail to block infection by A.27. Our data emphasize the need for continued global monitoring of novel lineages because of the independent evolution of new escape mutations.

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Antibody escape and global spread of SARS-CoV-2 lineage A.27

Abstract

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