Antibody-linked spherical nucleic acids for cellular targeting

Ke Zhang, Liangliang Hao, Sarah J. Hurst, Chad A. Mirkin*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

119 Scopus citations


Spherical nucleic acid (SNA) constructs are promising new single entity gene regulation materials capable of both cellular transfection and gene knockdown, but thus far are promiscuous structures, exhibiting excellent genetic but little cellular selectivity. In this communication, we describe a strategy to impart targeting capabilities to these constructs through noncovalent functionalization with a complementary antibody-DNA conjugate. As a proof-of-concept, we designed HER2-targeting SNAs and demonstrated that such structures exhibit cell type selectivity in terms of their uptake, and significantly greater gene knockdown in cells overexpressing the target antigen as compared to the analogous antibody-free and off-target materials.

Original languageEnglish (US)
Pages (from-to)16488-16491
Number of pages4
JournalJournal of the American Chemical Society
Issue number40
StatePublished - Oct 10 2012

ASJC Scopus subject areas

  • Catalysis
  • Chemistry(all)
  • Biochemistry
  • Colloid and Surface Chemistry


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