Antibody targeting soluble NKG2D ligand sMIC refuels and invigorates the endogenous immune system to fight cancer

Jennifer Wu

doi:10.1080/2162402X.2015.1095434

Antibody targeting soluble NKG2D ligand sMIC refuels and invigorates the endogenous immune system to fight cancer

Jennifer Wu^*

^*Corresponding author for this work

Urology

Research output: Contribution to journal › Article › peer-review

9 Scopus citations

Abstract

ABSTRACT: Human tumor-derived soluble NKG2D sMIC paralyzes the immune system through multiple pathways. Targeting soluble MIC with a nonblocking sMIC-neutralizing anti-MIC antibody effectuated and revamped endogenous innate and adoptive antitumor responses. Therapy induced regression of primary tumors and eliminated metastasis in preclinical models.

Original language	English (US)
Journal	OncoImmunology
Volume	5
Issue number	3
DOIs	https://doi.org/10.1080/2162402X.2015.1095434
State	Published - Mar 3 2016

Keywords

Cancer immunotherapy
NKG2D ligands
nonblocking sMIC-neutralizing anti-MIC antibody
soluble MIC

ASJC Scopus subject areas

Immunology and Allergy
Immunology
Oncology

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abstract = "ABSTRACT: Human tumor-derived soluble NKG2D sMIC paralyzes the immune system through multiple pathways. Targeting soluble MIC with a nonblocking sMIC-neutralizing anti-MIC antibody effectuated and revamped endogenous innate and adoptive antitumor responses. Therapy induced regression of primary tumors and eliminated metastasis in preclinical models.",

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AB - ABSTRACT: Human tumor-derived soluble NKG2D sMIC paralyzes the immune system through multiple pathways. Targeting soluble MIC with a nonblocking sMIC-neutralizing anti-MIC antibody effectuated and revamped endogenous innate and adoptive antitumor responses. Therapy induced regression of primary tumors and eliminated metastasis in preclinical models.

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KW - nonblocking sMIC-neutralizing anti-MIC antibody

KW - soluble MIC

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