Abstract
ABSTRACT: Human tumor-derived soluble NKG2D sMIC paralyzes the immune system through multiple pathways. Targeting soluble MIC with a nonblocking sMIC-neutralizing anti-MIC antibody effectuated and revamped endogenous innate and adoptive antitumor responses. Therapy induced regression of primary tumors and eliminated metastasis in preclinical models.
Original language | English (US) |
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Journal | OncoImmunology |
Volume | 5 |
Issue number | 3 |
DOIs | |
State | Published - Mar 3 2016 |
Keywords
- Cancer immunotherapy
- NKG2D ligands
- nonblocking sMIC-neutralizing anti-MIC antibody
- soluble MIC
ASJC Scopus subject areas
- Immunology and Allergy
- Immunology
- Oncology