Antibody targeting soluble NKG2D ligand sMIC refuels and invigorates the endogenous immune system to fight cancer

Jennifer Wu

doi:10.1080/2162402X.2015.1095434

Antibody targeting soluble NKG2D ligand sMIC refuels and invigorates the endogenous immune system to fight cancer

Jennifer Wu^*

^*Corresponding author for this work

Urology

Research output: Contribution to journal › Article › peer-review

10 Scopus citations

Abstract

ABSTRACT: Human tumor-derived soluble NKG2D sMIC paralyzes the immune system through multiple pathways. Targeting soluble MIC with a nonblocking sMIC-neutralizing anti-MIC antibody effectuated and revamped endogenous innate and adoptive antitumor responses. Therapy induced regression of primary tumors and eliminated metastasis in preclinical models.

Original language	English (US)
Journal	OncoImmunology
Volume	5
Issue number	3
DOIs	https://doi.org/10.1080/2162402X.2015.1095434
State	Published - Mar 3 2016

Keywords

Cancer immunotherapy
NKG2D ligands
nonblocking sMIC-neutralizing anti-MIC antibody
soluble MIC

ASJC Scopus subject areas

Immunology and Allergy
Immunology
Oncology

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

Access to Document

10.1080/2162402X.2015.1095434

Cite this

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abstract = "ABSTRACT: Human tumor-derived soluble NKG2D sMIC paralyzes the immune system through multiple pathways. Targeting soluble MIC with a nonblocking sMIC-neutralizing anti-MIC antibody effectuated and revamped endogenous innate and adoptive antitumor responses. Therapy induced regression of primary tumors and eliminated metastasis in preclinical models.",

keywords = "Cancer immunotherapy, NKG2D ligands, nonblocking sMIC-neutralizing anti-MIC antibody, soluble MIC",

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AU - Wu, Jennifer

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N2 - ABSTRACT: Human tumor-derived soluble NKG2D sMIC paralyzes the immune system through multiple pathways. Targeting soluble MIC with a nonblocking sMIC-neutralizing anti-MIC antibody effectuated and revamped endogenous innate and adoptive antitumor responses. Therapy induced regression of primary tumors and eliminated metastasis in preclinical models.

AB - ABSTRACT: Human tumor-derived soluble NKG2D sMIC paralyzes the immune system through multiple pathways. Targeting soluble MIC with a nonblocking sMIC-neutralizing anti-MIC antibody effectuated and revamped endogenous innate and adoptive antitumor responses. Therapy induced regression of primary tumors and eliminated metastasis in preclinical models.

KW - Cancer immunotherapy

KW - NKG2D ligands

KW - nonblocking sMIC-neutralizing anti-MIC antibody

KW - soluble MIC

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JO - OncoImmunology

JF - OncoImmunology

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Antibody targeting soluble NKG2D ligand sMIC refuels and invigorates the endogenous immune system to fight cancer

Abstract

Keywords

ASJC Scopus subject areas

UN SDGs

Access to Document

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