Antibody targeting soluble NKG2D ligand sMIC refuels and invigorates the endogenous immune system to fight cancer

Jennifer Wu*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

9 Scopus citations

Abstract

ABSTRACT: Human tumor-derived soluble NKG2D sMIC paralyzes the immune system through multiple pathways. Targeting soluble MIC with a nonblocking sMIC-neutralizing anti-MIC antibody effectuated and revamped endogenous innate and adoptive antitumor responses. Therapy induced regression of primary tumors and eliminated metastasis in preclinical models.

Original languageEnglish (US)
JournalOncoImmunology
Volume5
Issue number3
DOIs
StatePublished - Mar 3 2016

Keywords

  • Cancer immunotherapy
  • NKG2D ligands
  • nonblocking sMIC-neutralizing anti-MIC antibody
  • soluble MIC

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology
  • Oncology

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