Anticancer treatments and female fertility: clinical concerns and role of oncologists in oncofertility practice

Mahmoud Salama, Teresa K. Woodruff*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

22 Scopus citations


Introduction: Anticancer treatments such as aggressive chemotherapy and radiotherapy have deleterious gonadotoxic side effects and are considered the most common causes of pathological and iatrogenic fertility loss in women. Areas covered: In order to preserve fertility of young women and girls with cancer, several established, experimental, and debatable options can be offered in the emerging field of oncofertility. This article reviews the effects of anticancer treatments on female fertility and discusses the current challenges and future directions of fertility preservation options that can be offered to the female patients with cancer. Expert commentary: Although promising, several medical, economic, social and legal barriers face oncofertility practice around the globe especially in underserved areas. To overcome such barriers, more effective solutions should be provided to spread awareness and enhance communication between patients, oncologists and gynecologists. Early referral by oncologists before initiation of chemotherapy and radiotherapy is an important key factor for success in female fertility preservation strategies.

Original languageEnglish (US)
Pages (from-to)687-692
Number of pages6
JournalExpert review of anticancer therapy
Issue number8
StatePublished - Aug 3 2017


  • Anticancer treatments
  • female fertility loss
  • female fertility preservation
  • gonadotoxicity
  • oncofertility

ASJC Scopus subject areas

  • Oncology
  • Pharmacology (medical)

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