Antidepressant-like properties of prepro-TRH 178-199: Acute effects in the forced swim test

Eva Redei*, Mark Organ, Sharron Hart

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

7 Scopus citations

Abstract

THIS study examined the central effects of rat prepro-TRH 178-199, a peptide with corticotropin release inhibiting activity at the pituitary, on the Porsolt forced swim test (FST) of depressive behavior in rats. Subacute intracerebroventricular administration of prepro-TRH 178-199 dose- responsively reduced floating and increased active behaviors in the FST. Chronic administration of 6 μg/kg prepro-TRH 178-199 decreased floating more than subacute treatment, but there were no significant differences between chronic and subacute treatment effects on active behavior. Biological activity of this peptide resides in the C-terminal fragment as prepro-TRH 178-199 and prepro-TRH 191-199 were equally potent in the FST. These data suggest that endogenous prepro-TRH 178-199 with its antidepressant-like activity might contribute to the etiology or manifestation of depressive behavior.

Original languageEnglish (US)
Pages (from-to)3273-3276
Number of pages4
JournalNeuroReport
Volume10
Issue number16
DOIs
StatePublished - Jan 1 1999

Keywords

  • Behavior
  • Depression model
  • Forced swim test
  • Prepro-thyrotropin releasing hormone
  • Rat

ASJC Scopus subject areas

  • Neuroscience(all)

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