Antidiuretic hormone - V2-receptor - Aquaporin-2 system in rat kidneys during acute inflammation

A. V. Misharin*, A. B. Resnenko, O. V. Fidelina, V. V. Grinevich, I. G. Akmaev

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

8 Scopus citations

Abstract

Expression of antidiuretic hormone V2-receptor, water channel protein aquaporin-2, and cytokines interleukin-1β and interleukin-6 was studied in the kidneys of rats with acute inflammation produced by intraperitoneal injection of lipopolysaccharide in a dose of 250 μg/100 g. Reduced expression of aquaporin-2 and V2-receptor led to impairment of concentration capacity in the kidneys and decrease in urine osmolarity.

Original languageEnglish (US)
Pages (from-to)452-456
Number of pages5
JournalBulletin of Experimental Biology and Medicine
Volume138
Issue number5
DOIs
StatePublished - Nov 2004

Keywords

  • Aquaporin-2
  • Interleukin-1β
  • Interleukin-6
  • Lipopolysaccharide
  • Vasopressin V-receptor

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)

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