Antidiuretic hormone - V2-receptor - Aquaporin-2 system in rat kidneys during acute inflammation

A. V. Misharin; A. B. Resnenko; O. V. Fidelina; V. V. Grinevich; I. G. Akmaev

doi:10.1007/s10517-005-0068-x

Antidiuretic hormone - V₂-receptor - Aquaporin-2 system in rat kidneys during acute inflammation

A. V. Misharin^*, A. B. Resnenko, O. V. Fidelina, V. V. Grinevich, I. G. Akmaev

^*Corresponding author for this work

Medicine, Pulmonary Division

Research output: Contribution to journal › Article › peer-review

8 Scopus citations

Abstract

Expression of antidiuretic hormone V₂-receptor, water channel protein aquaporin-2, and cytokines interleukin-1β and interleukin-6 was studied in the kidneys of rats with acute inflammation produced by intraperitoneal injection of lipopolysaccharide in a dose of 250 μg/100 g. Reduced expression of aquaporin-2 and V₂-receptor led to impairment of concentration capacity in the kidneys and decrease in urine osmolarity.

Original language	English (US)
Pages (from-to)	452-456
Number of pages	5
Journal	Bulletin of Experimental Biology and Medicine
Volume	138
Issue number	5
DOIs	https://doi.org/10.1007/s10517-005-0068-x
State	Published - Nov 2004

Funding

This work was supported by the Russian Foundation for Basic Research (grant No. 03-04-48009a).

Keywords

Aquaporin-2
Interleukin-1β
Interleukin-6
Lipopolysaccharide
Vasopressin V-receptor

ASJC Scopus subject areas

General Biochemistry, Genetics and Molecular Biology

Access to Document

10.1007/s10517-005-0068-x

Cite this

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title = "Antidiuretic hormone - V2-receptor - Aquaporin-2 system in rat kidneys during acute inflammation",

abstract = "Expression of antidiuretic hormone V2-receptor, water channel protein aquaporin-2, and cytokines interleukin-1β and interleukin-6 was studied in the kidneys of rats with acute inflammation produced by intraperitoneal injection of lipopolysaccharide in a dose of 250 μg/100 g. Reduced expression of aquaporin-2 and V2-receptor led to impairment of concentration capacity in the kidneys and decrease in urine osmolarity.",

keywords = "Aquaporin-2, Interleukin-1β, Interleukin-6, Lipopolysaccharide, Vasopressin V-receptor",

author = "Misharin, {A. V.} and Resnenko, {A. B.} and Fidelina, {O. V.} and Grinevich, {V. V.} and Akmaev, {I. G.}",

note = "Funding Information: This work was supported by the Russian Foundation for Basic Research (grant No. 03-04-48009a).",

year = "2004",

month = nov,

doi = "10.1007/s10517-005-0068-x",

language = "English (US)",

volume = "138",

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T1 - Antidiuretic hormone - V2-receptor - Aquaporin-2 system in rat kidneys during acute inflammation

AU - Misharin, A. V.

AU - Resnenko, A. B.

AU - Fidelina, O. V.

AU - Grinevich, V. V.

AU - Akmaev, I. G.

N1 - Funding Information: This work was supported by the Russian Foundation for Basic Research (grant No. 03-04-48009a).

PY - 2004/11

Y1 - 2004/11

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AB - Expression of antidiuretic hormone V2-receptor, water channel protein aquaporin-2, and cytokines interleukin-1β and interleukin-6 was studied in the kidneys of rats with acute inflammation produced by intraperitoneal injection of lipopolysaccharide in a dose of 250 μg/100 g. Reduced expression of aquaporin-2 and V2-receptor led to impairment of concentration capacity in the kidneys and decrease in urine osmolarity.

KW - Aquaporin-2

KW - Interleukin-1β

KW - Interleukin-6

KW - Lipopolysaccharide

KW - Vasopressin V-receptor

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