Antifouling Surface Coatings from Self-Assembled Zwitterionic Aramid Amphiphile Nanoribbons

Ty Christoff-Tempesta; Elad Deiss-Yehiely; Pierre C. Dromel; Linnaea D. Uliassi; Cécile A.C. Chazot; Eveline Postelnicu; A. John Hart; Myron Spector; Paula T. Hammond; Julia H. Ortony

doi:10.1002/admi.202200311

Antifouling Surface Coatings from Self-Assembled Zwitterionic Aramid Amphiphile Nanoribbons

Ty Christoff-Tempesta, Elad Deiss-Yehiely, Pierre C. Dromel, Linnaea D. Uliassi, Cécile A.C. Chazot, Eveline Postelnicu, A. John Hart, Myron Spector, Paula T. Hammond, Julia H. Ortony^*

^*Corresponding author for this work

Materials Science and Engineering

Research output: Contribution to journal › Article › peer-review

6 Scopus citations

Abstract

Zwitterionic surfaces are increasingly explored as antifouling coatings due to their propensity to resist protein, bacterial, and cell adhesion and are typically applied as polymeric systems. Here, the self-assembly of strongly interacting small molecule amphiphiles is reported to produce nanoribbons for antifouling applications. Synthesized amphiphiles spontaneously form micrometers-long nanoribbons with nanometer-scale cross-sections and intrinsically display a dense coating of zwitterionic moieties on their surfaces. Substrates coated with nanoribbons demonstrate concentration-dependent thicknesses and near superhydrophilicity. These surface coatings are then probed for antifouling properties and substantial reductions are demonstrated in protein adsorption, bacterial biofilm formation, and cell adhesion relative to uncoated controls. Harnessing cohesive small molecule self-assembling nanomaterials for surface coatings offers a facile route to effective antifouling surfaces.

Original language	English (US)
Article number	2200311
Journal	Advanced Materials Interfaces
Volume	9
Issue number	22
DOIs	https://doi.org/10.1002/admi.202200311
State	Published - Aug 3 2022

Funding

The authors thank Dr. Deepti Singh for her assistance in cell preparation and culturing for fluorescence microscopy imaging. The authors also thank Dr. Tiffany Amariuta and Eric Bartell for their assistance with statistical analysis. This material is based upon work supported by the National Science Foundation under Grant No. CHE‐1945500. This work was supported in part by the Professor Amar G. Bose Research Grant Program. T.C.‐T. acknowledges the support of the Hugh Hampton Young Fellowship and the National Science Foundation Graduate Research Fellowship Program under Grant No. 1122374. E.D.‐Y. acknowledges the National Research Foundation, Prime Minister's Office, Singapore for support under its Campus for Research Excellence and Technological Enterprise (CREATE) programme. C.A.C.C. acknowledges the support of the 2021–2022 MathWorks Engineering Fellowship at the Massachusetts Institute of Technology (MIT). This work made use of the Materials Research Science and Engineering Center Shared Experimental Facilities at MIT supported by the National Science Foundation under award number DMR‐14‐19807 and the MIT Department of Chemistry Instrumentation Facility. X‐ray scattering measurements were performed at beamline 12‐ID‐B of the Advanced Photon Source, a US Department of Energy Office of Science User Facility operated for the US Department of Energy Office of Science by Argonne National Laboratory under Contract No. DE‐AC02‐06CH11357. This work was performed in part at the Harvard University Center for Nanoscale Systems cryo‐TEM facility, a member of the National Nanotechnology Coordinated Infrastructure Network, which was supported by the National Science Foundation under Award No. 1541959. The final panel of the Table of Contents figure was created with BioRender.com.

Keywords

antifouling
self-assembly
supramolecular nanoribbons
surface coatings
zwitterionic

ASJC Scopus subject areas

Mechanics of Materials
Mechanical Engineering

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10.1002/admi.202200311

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title = "Antifouling Surface Coatings from Self-Assembled Zwitterionic Aramid Amphiphile Nanoribbons",

abstract = "Zwitterionic surfaces are increasingly explored as antifouling coatings due to their propensity to resist protein, bacterial, and cell adhesion and are typically applied as polymeric systems. Here, the self-assembly of strongly interacting small molecule amphiphiles is reported to produce nanoribbons for antifouling applications. Synthesized amphiphiles spontaneously form micrometers-long nanoribbons with nanometer-scale cross-sections and intrinsically display a dense coating of zwitterionic moieties on their surfaces. Substrates coated with nanoribbons demonstrate concentration-dependent thicknesses and near superhydrophilicity. These surface coatings are then probed for antifouling properties and substantial reductions are demonstrated in protein adsorption, bacterial biofilm formation, and cell adhesion relative to uncoated controls. Harnessing cohesive small molecule self-assembling nanomaterials for surface coatings offers a facile route to effective antifouling surfaces.",

keywords = "antifouling, self-assembly, supramolecular nanoribbons, surface coatings, zwitterionic",

author = "Ty Christoff-Tempesta and Elad Deiss-Yehiely and Dromel, {Pierre C.} and Uliassi, {Linnaea D.} and Chazot, {C{\'e}cile A.C.} and Eveline Postelnicu and Hart, {A. John} and Myron Spector and Hammond, {Paula T.} and Ortony, {Julia H.}",

note = "Funding Information: The authors thank Dr. Deepti Singh for her assistance in cell preparation and culturing for fluorescence microscopy imaging. The authors also thank Dr. Tiffany Amariuta and Eric Bartell for their assistance with statistical analysis. This material is based upon work supported by the National Science Foundation under Grant No. CHE‐1945500. This work was supported in part by the Professor Amar G. Bose Research Grant Program. T.C.‐T. acknowledges the support of the Hugh Hampton Young Fellowship and the National Science Foundation Graduate Research Fellowship Program under Grant No. 1122374. E.D.‐Y. acknowledges the National Research Foundation, Prime Minister's Office, Singapore for support under its Campus for Research Excellence and Technological Enterprise (CREATE) programme. C.A.C.C. acknowledges the support of the 2021–2022 MathWorks Engineering Fellowship at the Massachusetts Institute of Technology (MIT). This work made use of the Materials Research Science and Engineering Center Shared Experimental Facilities at MIT supported by the National Science Foundation under award number DMR‐14‐19807 and the MIT Department of Chemistry Instrumentation Facility. X‐ray scattering measurements were performed at beamline 12‐ID‐B of the Advanced Photon Source, a US Department of Energy Office of Science User Facility operated for the US Department of Energy Office of Science by Argonne National Laboratory under Contract No. DE‐AC02‐06CH11357. This work was performed in part at the Harvard University Center for Nanoscale Systems cryo‐TEM facility, a member of the National Nanotechnology Coordinated Infrastructure Network, which was supported by the National Science Foundation under Award No. 1541959. The final panel of the Table of Contents figure was created with BioRender.com. Publisher Copyright: {\textcopyright} 2022 The Authors. Advanced Materials Interfaces published by Wiley-VCH GmbH.",

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AU - Deiss-Yehiely, Elad

AU - Dromel, Pierre C.

AU - Uliassi, Linnaea D.

AU - Chazot, Cécile A.C.

AU - Postelnicu, Eveline

AU - Hart, A. John

AU - Spector, Myron

AU - Hammond, Paula T.

AU - Ortony, Julia H.

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N2 - Zwitterionic surfaces are increasingly explored as antifouling coatings due to their propensity to resist protein, bacterial, and cell adhesion and are typically applied as polymeric systems. Here, the self-assembly of strongly interacting small molecule amphiphiles is reported to produce nanoribbons for antifouling applications. Synthesized amphiphiles spontaneously form micrometers-long nanoribbons with nanometer-scale cross-sections and intrinsically display a dense coating of zwitterionic moieties on their surfaces. Substrates coated with nanoribbons demonstrate concentration-dependent thicknesses and near superhydrophilicity. These surface coatings are then probed for antifouling properties and substantial reductions are demonstrated in protein adsorption, bacterial biofilm formation, and cell adhesion relative to uncoated controls. Harnessing cohesive small molecule self-assembling nanomaterials for surface coatings offers a facile route to effective antifouling surfaces.

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Antifouling Surface Coatings from Self-Assembled Zwitterionic Aramid Amphiphile Nanoribbons

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