Antigen-specific tolerance strategies for the prevention and treatment of autoimmune disease

Stephen D. Miller*, Danielle M. Turley, Joseph R. Podojil

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review

199 Scopus citations


The development of safe and effective antigen-specific therapies is needed to treat patients with autoimmune diseases. These therapies must allow for the specific tolerization of self-reactive immune cells without altering host immunity to infectious insults. Experimental models and clinical trials for the treatment of autoimmune disease have identified putative mechanisms by which antigen-specific therapies induce tolerance. Although advances have been made in the development of efficient antigen-specific therapies, translating these therapies from bench to bedside has remained difficult. Here, we discuss the recent advances in our understanding of antigen-specific therapies for the treatment of autoimmune diseases.

Original languageEnglish (US)
Pages (from-to)665-677
Number of pages13
JournalNature Reviews Immunology
Issue number9
StatePublished - Sep 2007

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology

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