Antigonadal Effect of Melatonin in Pinealectomized and Intact Male Hamsters

Fred W. Turek

doi:10.3181/00379727-155-39738

Antigonadal Effect of Melatonin in Pinealectomized and Intact Male Hamsters

Fred W. Turek^*

^*Corresponding author for this work

Neurobiology

Research output: Contribution to journal › Article › peer-review

12 Scopus citations

Abstract

The administration of mela-tonin (12-150 μg/day) via subcutaneous Si-lastic capsules inhibited photic-induced testicular recrudescence to the same degree in both pinealectomized and intact hamsters. Melatonin (300 μg/day) also induced marked testicular regression in sexually mature intact and pinealectomized hamsters maintained on a photostimulatory LD 14:10 light cycle. The similar responses of pinealectomized and intact hamsters to melatonin treatment indicate that the effects of exogenous melatonin are not mediated via the pineal gland.

Original language	English (US)
Pages (from-to)	31-34
Number of pages	4
Journal	Proceedings of the Society for Experimental Biology and Medicine
Volume	155
Issue number	1
DOIs	https://doi.org/10.3181/00379727-155-39738
State	Published - May 1977

Funding

This investigation was supported by NSF Research Grant PCM-09955, NIH Grant 09885, and by a grant from the Office of Research and Sponsored Programs, Northwestern University.

ASJC Scopus subject areas

General Biochemistry, Genetics and Molecular Biology

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title = "Antigonadal Effect of Melatonin in Pinealectomized and Intact Male Hamsters",

abstract = "The administration of mela-tonin (12-150 μg/day) via subcutaneous Si-lastic capsules inhibited photic-induced testicular recrudescence to the same degree in both pinealectomized and intact hamsters. Melatonin (300 μg/day) also induced marked testicular regression in sexually mature intact and pinealectomized hamsters maintained on a photostimulatory LD 14:10 light cycle. The similar responses of pinealectomized and intact hamsters to melatonin treatment indicate that the effects of exogenous melatonin are not mediated via the pineal gland.",

author = "Turek, {Fred W.}",

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N2 - The administration of mela-tonin (12-150 μg/day) via subcutaneous Si-lastic capsules inhibited photic-induced testicular recrudescence to the same degree in both pinealectomized and intact hamsters. Melatonin (300 μg/day) also induced marked testicular regression in sexually mature intact and pinealectomized hamsters maintained on a photostimulatory LD 14:10 light cycle. The similar responses of pinealectomized and intact hamsters to melatonin treatment indicate that the effects of exogenous melatonin are not mediated via the pineal gland.

AB - The administration of mela-tonin (12-150 μg/day) via subcutaneous Si-lastic capsules inhibited photic-induced testicular recrudescence to the same degree in both pinealectomized and intact hamsters. Melatonin (300 μg/day) also induced marked testicular regression in sexually mature intact and pinealectomized hamsters maintained on a photostimulatory LD 14:10 light cycle. The similar responses of pinealectomized and intact hamsters to melatonin treatment indicate that the effects of exogenous melatonin are not mediated via the pineal gland.

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Antigonadal Effect of Melatonin in Pinealectomized and Intact Male Hamsters

Abstract

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