Abstract
Antineutrophil antibodies were detected in the serum of 12 of 14 patients with acute Epstein-Barr virus-induced infectious mononucleosis. These antibodies were present in two patients with mononucleosis and severe neutropenia, and in 10 patients with mononucleosis uncomplicated by severe neutropenia. Antineutrophil antibodies were not detected in serum from five patients with cytomegalovirus-induced mononucleosis, or five renal allograft recipients with primary or reactivation Epstein-Barr virus infection. This study suggests that antineutrophil antibodies are among those produced by the polyclonal activation induced by Epstein-Barr virus during acute infectious mononucleosis.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 85-90 |
| Number of pages | 6 |
| Journal | The American journal of medicine |
| Volume | 76 |
| Issue number | 1 |
| DOIs | |
| State | Published - Jan 1984 |
Funding
From the Infectious Disease and Hematology-Oncology Units, Medical Services, Massachusetts General Hospital and Harvard Medical School, and the Division of Infectious Diseases, Department of Medicine, Boston University Medical Center, Boston, Massachusetts; and the Children’s Hospital of Philadelphia and the School of Medicine of the University of Pennsylvania, Philadelphia, Pennsylvania. This work was supported by United States Health Services Grants Al 17057, CA 12464, Al 16476, and CA 33324. Requests for reprints should be addressed to Dr. Robert T. Schooley, Infectious Disease Unit, Massachusetts General Hospital, Fruit Street, Boston Massachusetts 02114. Manuscript accepted June 29, 1963.
ASJC Scopus subject areas
- General Medicine