Antioxidant approaches for the treatment of Alzheimers disease

Hyun Pil Lee, Xiongwei Zhu, Gemma Casadesus, Rudy J. Castellani, Akihiko Nunomura, Mark A. Smith, Hyoung Gon Lee, George Perry*

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review

93 Scopus citations

Abstract

Oxidative stress is an important factor, and one that acts in the earliest stages, of Alzheimers disease (AD) pathogenesis. The reduction of oxidative stress has been tested as a therapy for AD. While the trial of vitamin E supplementation in moderately severe AD is the most promising so far, it also reveals the limitations of general antioxidant therapies that simply lower oxidative stress and, therefore, the complexity of the redox system. The multiple contributing factors that foster the clinical manifestations of AD should be considered when designing antioxidative stress therapy. In this article, we discuss the multiple pathogenic mechanisms of oxidative stress in AD and the potential targeting approaches.

Original languageEnglish (US)
Pages (from-to)1201-1208
Number of pages8
JournalExpert Review of Neurotherapeutics
Volume10
Issue number7
DOIs
StatePublished - Jul 2010

Keywords

  • Alzheimers disease
  • antioxidants
  • oxidative stress
  • therapeutics

ASJC Scopus subject areas

  • Clinical Neurology
  • Pharmacology (medical)
  • General Neuroscience

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