Antioxidant Polymers as Biomaterial

Robert van Lith*, Guillermo Antonio Ameer

*Corresponding author for this work

Research output: Chapter in Book/Report/Conference proceedingChapter

10 Scopus citations

Abstract

In this chapter, an overview will be given of progress in the development of antioxidant polymers and their therapeutic use. Oxidative stress has been identified as a key player in many disease conditions, as well as a result of commonly used implantable biomaterials. Systemic delivery of antioxidants is hampered by poor absorption, loss of bioactivity, limited time frame of effectiveness, and nontargeted lowering of oxidative stress. For this reason, polymers are being developed for localized, sustained antioxidant activity. Antioxidant entrapment in polymers will be discussed, as well as development of polymers with intrinsic antioxidant activity, with an emphasis on the latter.

Original languageEnglish (US)
Title of host publicationOxidative Stress and Biomaterials
PublisherElsevier.
Pages251-296
Number of pages46
ISBN (Electronic)9780128032701
ISBN (Print)9780128032695
DOIs
StatePublished - Jun 1 2016

Keywords

  • Antioxidant enzyme
  • Antioxidant polymer
  • Biomaterial
  • Metal chelation
  • Oxidative stress
  • Reactive oxygen species
  • Vitamin

ASJC Scopus subject areas

  • Engineering(all)
  • Materials Science(all)

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