Antiphospholipid Antibodies and Arterial Thrombosis: Case Reports and a Review of the Literature

Gregory S. McGee, William H. Pearce*, Leena Sharma, David Green, James S.T. Yao

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

34 Scopus citations


Antiphospholipid antibodies are a relatively heterogeneous mix of immunoglobulins with binding specificities for negatively charged or neutral phospholipids. Currently, the most commonly detected antiphospholipid antibodies include the anticardiolipin antibody, the lupus anticoagulant, and an antibody implicated in false-positive VDRL testing. Recently, a clinical syndrome of vaso-occlusive disorders associated with antiphospholipid antibodies has been identified and may result from immune-mediated disruption of endothelial function. This clinical syndrome encompasses arterial and venous thrombosis, recurrent fetal loss, neurologic dysfunction (eg, migraine, chorea, and encephalopathy), systemic and pulmonary arterial hypertension, and endocardial disease. Although most commonly associated with systemic lupus erythematosus, the antiphospholipid antibody syndrome also has been identified in patients with vaso-occlusive disease without systemic lupus erythematosus. Recently, identification of antiphospholipid antibodies has been facilitated by the development of a more sensitive assay for anticardiolipin antibody. In this article, case histories of three patients with arterial thrombosis and associated anticardiolipin antibodies, including the first associated case of terminal aortic thrombosis, are reviewed and the subject of the antiphospholipid antibody syndrome is discussed.

Original languageEnglish (US)
Pages (from-to)342-346
Number of pages5
JournalArchives of Surgery
Issue number3
StatePublished - Mar 1992

ASJC Scopus subject areas

  • Surgery


Dive into the research topics of 'Antiphospholipid Antibodies and Arterial Thrombosis: Case Reports and a Review of the Literature'. Together they form a unique fingerprint.

Cite this