Antiretroviral resistance associated with supervised treatment interruptions in treated acute HIV infection

Cecile L. Tremblay*, Jennifer L. Hicks, Lorraine Sutton, Francoise Giguel, Theresa Flynn, Mary Johnston, Paul E. Sax, Bruce D. Walker, Martin S. Hirsch, Eric S. Rosenberg, Richard T. D'Aquila

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

25 Scopus citations

Abstract

We studied 14 patients acutely infected with wild-type HIV, who underwent supervised treatment interruptions after initial antiretroviral treatment including lamivudine. Lamivudine resistance mutations emerged for the first time during supervised treatment interruptions in one patient. Resistance should be monitored in supervised treatment interruptions trials, because mutations may first be detected only after therapy is interrupted.

Original languageEnglish (US)
Pages (from-to)1086-1089
Number of pages4
JournalAIDS
Volume17
Issue number7
DOIs
StatePublished - May 2 2003

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology
  • Infectious Diseases

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