Antiretroviral therapy and the prevalence and incidence of diabetes mellitus in the multicenter AIDS cohort study

Todd T. Brown*, Stephen R. Cole, Xiuhong Li, Lawrence A. Kingsley, Frank J. Palella, Sharon A. Riddler, Barbara R. Visscher, Joseph B. Margolick, Adrian S. Dobs

*Corresponding author for this work

Research output: Contribution to journalArticle

541 Scopus citations

Abstract

Background: The risk of diabetes mellitus (DM) in human immunodeficiency virus (HIV)-infected patients receiving highly active antiretroviral therapy (HAART) has not been well defined. Methods: We conducted an analysis in the Multicenter AIDS Cohort Study to determine the prevalence and incidence of DM in this cohort of HIV-infected and HIV-seronegative men. Prevalence analysis included 1278 men (710 HIV seronegative and 568 HIV infected, 411 receiving HAART) with fasting glucose concentration determinations at baseline. Incidence analysis included 680 of these 1278 men who at the baseline visit had a fasting glucose concentration of 98 mg/dL (5.4 mmol/L) or less, no self-reported history of DM, and no self-reported use of antidiabetic medication. Diabetes mellitus was defined as a fasting glucose concentration of 126 mg/dL (7 mmol/L) or higher, self-reported diagnosis of DM, or self-reported use of antidiabetic medication. Results: Fifty-seven (14%) of the 411 HIV-infected men using HAART at the baseline visit had prevalent DM compared with 33 (5%) of the 711 HIV-serpnegative men (prevalence ratio = 4.6; 95% confidence interval, 3.0-7.1, adjusted for age and body mass index[calculated as weight in kilograms divided by the square of height in meters]). The rate of incident DM was 4.7 cases per 100 person-years among HIV-infected men using HAART compared with 1.4 cases per 100 person-years among HIV-seronegative men (rate ratio = 4.11; 95% confidence interval, 1.85-9.16, adjusted for age and body mass index), during the 4-year observation period, based on a median follow-up of 2.3 years. Conclusion: The incidence of DM in HIV-infected men with HAART exposure was greater than 4 times that of HIV-seronegative men, representing a risk that is higher than previous estimates.

Original languageEnglish (US)
Pages (from-to)1179-1184
Number of pages6
JournalArchives of Internal Medicine
Volume165
Issue number10
DOIs
StatePublished - May 23 2005

ASJC Scopus subject areas

  • Internal Medicine

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    Brown, T. T., Cole, S. R., Li, X., Kingsley, L. A., Palella, F. J., Riddler, S. A., Visscher, B. R., Margolick, J. B., & Dobs, A. S. (2005). Antiretroviral therapy and the prevalence and incidence of diabetes mellitus in the multicenter AIDS cohort study. Archives of Internal Medicine, 165(10), 1179-1184. https://doi.org/10.1001/archinte.165.10.1179