Anti‐SS‐A antibodies and fetal outcome in maternal systemic lupus erythematosus

Rosalind Ramsey‐Goldman; David Hom; Jau‐Shyong ‐S Deng; Gayle Casterline Ziegler; Leslie E. Kahl; Virginia D. Steen; Ronald E. Laporte; THOMAS A. Medsger

doi:10.1002/art.1780291013

Anti‐SS‐A antibodies and fetal outcome in maternal systemic lupus erythematosus

Rosalind Ramsey‐Goldman^*, David Hom, Jau‐Shyong ‐S Deng, Gayle Casterline Ziegler, Leslie E. Kahl, Virginia D. Steen, Ronald E. Laporte, THOMAS A. Medsger

^*Corresponding author for this work

Medicine, Rheumatology Division

Research output: Contribution to journal › Article › peer-review

149 Scopus citations

Abstract

In 155 women with systemic lupus erythematosus, there were no significant differences in the rates of fertility or adverse fetal outcome between the 47 (30%) with serum anti‐SS‐A antibody and the 108 without anti‐SS‐A, except in the frequency of congenital heart block. This complication occurred in 6 of 96 pregnancies in women with anti‐SS‐A and was associated with high‐titer maternal antibody. The overall risk of a woman with lupus having an infant with congenital heart block was estimated to be 1:60, but the risk was considerably higher (1:20) if anti‐SS‐A antibody was present.

Original language	English (US)
Pages (from-to)	1269-1273
Number of pages	5
Journal	Arthritis & Rheumatism
Volume	29
Issue number	10
DOIs	https://doi.org/10.1002/art.1780291013
State	Published - Oct 1986

ASJC Scopus subject areas

Immunology and Allergy
Rheumatology
Immunology
Pharmacology (medical)

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title = "Anti‐SS‐A antibodies and fetal outcome in maternal systemic lupus erythematosus",

abstract = "In 155 women with systemic lupus erythematosus, there were no significant differences in the rates of fertility or adverse fetal outcome between the 47 (30%) with serum anti‐SS‐A antibody and the 108 without anti‐SS‐A, except in the frequency of congenital heart block. This complication occurred in 6 of 96 pregnancies in women with anti‐SS‐A and was associated with high‐titer maternal antibody. The overall risk of a woman with lupus having an infant with congenital heart block was estimated to be 1:60, but the risk was considerably higher (1:20) if anti‐SS‐A antibody was present.",

author = "Rosalind Ramsey‐Goldman and David Hom and Deng, {Jau‐Shyong ‐S} and Ziegler, {Gayle Casterline} and Kahl, {Leslie E.} and Steen, {Virginia D.} and Laporte, {Ronald E.} and Medsger, {THOMAS A.}",

year = "1986",

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T1 - Anti‐SS‐A antibodies and fetal outcome in maternal systemic lupus erythematosus

AU - Ramsey‐Goldman, Rosalind

AU - Hom, David

AU - Deng, Jau‐Shyong ‐S

AU - Ziegler, Gayle Casterline

AU - Kahl, Leslie E.

AU - Steen, Virginia D.

AU - Laporte, Ronald E.

AU - Medsger, THOMAS A.

PY - 1986/10

Y1 - 1986/10

N2 - In 155 women with systemic lupus erythematosus, there were no significant differences in the rates of fertility or adverse fetal outcome between the 47 (30%) with serum anti‐SS‐A antibody and the 108 without anti‐SS‐A, except in the frequency of congenital heart block. This complication occurred in 6 of 96 pregnancies in women with anti‐SS‐A and was associated with high‐titer maternal antibody. The overall risk of a woman with lupus having an infant with congenital heart block was estimated to be 1:60, but the risk was considerably higher (1:20) if anti‐SS‐A antibody was present.

AB - In 155 women with systemic lupus erythematosus, there were no significant differences in the rates of fertility or adverse fetal outcome between the 47 (30%) with serum anti‐SS‐A antibody and the 108 without anti‐SS‐A, except in the frequency of congenital heart block. This complication occurred in 6 of 96 pregnancies in women with anti‐SS‐A and was associated with high‐titer maternal antibody. The overall risk of a woman with lupus having an infant with congenital heart block was estimated to be 1:60, but the risk was considerably higher (1:20) if anti‐SS‐A antibody was present.

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Anti‐SS‐A antibodies and fetal outcome in maternal systemic lupus erythematosus

Abstract

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