In 155 women with systemic lupus erythematosus, there were no significant differences in the rates of fertility or adverse fetal outcome between the 47 (30%) with serum anti‐SS‐A antibody and the 108 without anti‐SS‐A, except in the frequency of congenital heart block. This complication occurred in 6 of 96 pregnancies in women with anti‐SS‐A and was associated with high‐titer maternal antibody. The overall risk of a woman with lupus having an infant with congenital heart block was estimated to be 1:60, but the risk was considerably higher (1:20) if anti‐SS‐A antibody was present.
|Original language||English (US)|
|Number of pages||5|
|Journal||Arthritis & Rheumatism|
|State||Published - Oct 1986|
ASJC Scopus subject areas
- Immunology and Allergy
- Pharmacology (medical)