Anti‐SS‐A antibodies and fetal outcome in maternal systemic lupus erythematosus

Rosalind Ramsey‐Goldman*, David Hom, Jau‐Shyong ‐S Deng, Gayle Casterline Ziegler, Leslie E. Kahl, Virginia D. Steen, Ronald E. Laporte, THOMAS A. Medsger

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

138 Scopus citations

Abstract

In 155 women with systemic lupus erythematosus, there were no significant differences in the rates of fertility or adverse fetal outcome between the 47 (30%) with serum anti‐SS‐A antibody and the 108 without anti‐SS‐A, except in the frequency of congenital heart block. This complication occurred in 6 of 96 pregnancies in women with anti‐SS‐A and was associated with high‐titer maternal antibody. The overall risk of a woman with lupus having an infant with congenital heart block was estimated to be 1:60, but the risk was considerably higher (1:20) if anti‐SS‐A antibody was present.

Original languageEnglish (US)
Pages (from-to)1269-1273
Number of pages5
JournalArthritis & Rheumatism
Volume29
Issue number10
DOIs
StatePublished - Oct 1986

ASJC Scopus subject areas

  • Immunology and Allergy
  • Rheumatology
  • Immunology
  • Pharmacology (medical)

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