Antisynthetase syndrome: Pulmonary computed tomography findings of adult patients with antibodies to aminoacyl-tRNA synthetases

Yuko Waseda*, Takeshi Johkoh, Ryoko Egashira, Hiromitsu Sumikawa, Keigo Saeki, Satoshi Watanabe, Ryo Matsunuma, Hazuki Takato, Yukari Ichikawa, Yasuhito Hamaguchi, Akira Shiraki, Yoshinao Muro, Masahide Yasui, Helmut Prosch, Christian Herold, Kazuo Kasahara

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

69 Scopus citations


Objectives To describe the pulmonary CT findings in patients with anti-ARS-antibody-positive interstitial lung disease (anti-ARS-ILD) Methods The CT findings of 64 patients with anti-ARS-ILD were retrospectively reviewed. The images were retrospectively reviewed independently by 2 chest radiologists, and the final decision on the CT findings was made by a third chest radiologist. Results There were 16 male and 48 female patients, aged 54.2 ± 13.4 years. Sixteen patients had anti Jo-1, 24 had anti-EJ, 9 had anti-PL-7, 7 had anti-PL-12, 5 had anti-KS, and 3 had anti-OJ antibodies. Overall, 63 patients (98.4%) had CT findings predominantly in the lower lobe; 61 patients (95.3%) showed peripheral opacities, and 47 patients (73.4%) showed peribronchovascular opacities. Ground-glass attenuation, consolidation, and reticulation showed similar distribution patterns. Regarding detailed CT findings, 89.1% of patients had lower volume loss, 76.6% had interlobular septal thickening, and 67.2% had thickening of bronchovascular bundles. The final radiologic diagnoses were as follows: inconsistent with usual interstitial pneumonia (UIP) in 63 patients (98.4%), which included nonspecific interstitial pneumonia (NSIP) in 35 patients (55.6%), organizing pneumonia (OP) in 4 patients (6.3%), and OP with fibrosis in 22 patients (34.9%). Conclusions The characteristic CT findings of patients with anti-ARS-ILD were areas of ground-glass attenuation and reticulation, predominantly distributed as lower and peribronchovascular lesions, which is compatible with NSIP. One-third of patients showed OP with fibrosis.

Original languageEnglish (US)
Pages (from-to)1421-1426
Number of pages6
JournalEuropean journal of radiology
Issue number8
StatePublished - Aug 1 2016


  • Aminoacyl-tRNA synthetases
  • Antisynthetase syndrome
  • Dermatomyositis
  • Interstitial lung disease
  • Polymyositis

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging


Dive into the research topics of 'Antisynthetase syndrome: Pulmonary computed tomography findings of adult patients with antibodies to aminoacyl-tRNA synthetases'. Together they form a unique fingerprint.

Cite this