Antitumor activity of ipatasertib combined with chemotherapy: results from a phase Ib study in solid tumors

S. J. Isakoff*, J. Tabernero, L. R. Molife, J. C. Soria, A. Cervantes, N. J. Vogelzang, M. R. Patel, M. Hussain, A. Baron, G. Argilés, P. R. Conkling, D. Sampath, D. Maslyar, P. Patel, W. Chan, S. Gendreau, L. Musib, N. Xu, H. Ma, K. LinJ. Bendell

*Corresponding author for this work

Research output: Contribution to journalArticle

Abstract

Background: This phase Ib study evaluated the safety, tolerability, pharmacokinetics, and preliminary efficacy of the oral AKT inhibitor ipatasertib and chemotherapy or hormonal therapy in patients with advanced or metastatic solid tumors to determine combined dose-limiting toxicities (DLTs), maximum tolerated dose, and recommended phase II doses and schedules. Patients and methods: The clinical study comprised four combination treatment arms: arm A (with docetaxel), arm B [with mFOLFOX6 (modified leucovorin, 5-fluorouracil, and oxaliplatin)], arm C (with paclitaxel), and arm D (with enzalutamide). Primary endpoints were safety and tolerability; secondary endpoints were pharmacokinetics, clinical activity per Response Evaluation Criteria in Solid Tumors v1.1, and prostate-specific antigen levels. Results: In total, 122 patients were enrolled. Common adverse events were diarrhea, nausea, vomiting, decreased appetite, and fatigue. The safety profiles of the combination regimens were consistent with those of the background regimens, except for diarrhea, hyperglycemia, and rash, which were previously observed with ipatasertib treatment. The only combination DLT across all treatment arms was one event of grade 3 dehydration (ipatasertib 600 mg and paclitaxel). Recommended phase II doses for ipatasertib were 600 mg (and mFOLFOX6) and 400 mg (and paclitaxel), respectively. The maximum assessed dose of ipatasertib 600 mg combined with docetaxel or enzalutamide was well tolerated. Coadministration with enzalutamide (a cytochrome P450 3A inducer) resulted in approximately 50% lower ipatasertib exposure. Conclusions: Ipatasertib in combination with chemotherapy or hormonal therapy was well tolerated with a safety profile consistent with that of ATP-competitive AKT inhibitors. Clinical trial number: NCT01362374.

Original languageEnglish (US)
Pages (from-to)626-633
Number of pages8
JournalAnnals of Oncology
Volume31
Issue number5
DOIs
StatePublished - May 2020

Keywords

  • AKT inhibitor
  • advanced cancer
  • phase I

ASJC Scopus subject areas

  • Hematology
  • Oncology

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    Isakoff, S. J., Tabernero, J., Molife, L. R., Soria, J. C., Cervantes, A., Vogelzang, N. J., Patel, M. R., Hussain, M., Baron, A., Argilés, G., Conkling, P. R., Sampath, D., Maslyar, D., Patel, P., Chan, W., Gendreau, S., Musib, L., Xu, N., Ma, H., ... Bendell, J. (2020). Antitumor activity of ipatasertib combined with chemotherapy: results from a phase Ib study in solid tumors. Annals of Oncology, 31(5), 626-633. https://doi.org/10.1016/j.annonc.2020.02.007