Antiviral immune responses: Triggers of or triggered by autoimmunity?

Christian Münz*, Jan D. Lünemann, Meghann Teague Getts, Stephen D. Miller

*Corresponding author for this work

Research output: Contribution to journalReview article

297 Scopus citations

Abstract

The predisposition of individuals to several common autoimmune diseases, such as rheumatoid arthritis, systemic lupus erythematosus and multiple sclerosis, is genetically linked to certain human MHC class II molecules and other immune modulators. However, genetic predisposition is only one risk factor for the development of these diseases, and low concordance rates in monozygotic twins, as well as the geographical distribution of disease risk, suggest the involvement of environmental factors in the development of these diseases. Among these environmental factors, infections have been implicated in the onset and/or promotion of autoimmunity. In this Review, we outline the mechanisms by which viral infection can trigger autoimmune disease and describe the pathways by which infection and immune control of infectious disease might be dysregulated during autoimmunity.

Original languageEnglish (US)
Pages (from-to)246-258
Number of pages13
JournalNature Reviews Immunology
Volume9
Issue number4
DOIs
StatePublished - Apr 1 2009

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology

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